The Meta-analysis Of Simo Decoction On Patients With Functional Dyspepsia And The Study On Clinical Efficacy Of Simo Decoction On Patients With Functional Dyspepsia With Qi Stagnancy Of Both Liver And Spleen

Objective:Use Meta analysis to evaluate the clinical effect and safety of simotang for functional dyspepsia patients.To study the effect of Simo decoction(SD) on patients with functional dyspepsia with qi stagnancy of both liver and spleen and the influence of the SS and SP in the patients’ serum. To provide more basis for SD’s efficacy and safety on FD.Methods:We searched identify randomized controlled trials about simotang for FD patients. The methodological quality was assessed and the data was extracted according to the Cochrane Reviewer’s Handbook and related methods;84cases of FD with qi stagnancy of both liver and spleen were divided randomly into two groups:the treating group and the contrasting group. SD and simulative Domperidone was taken in the treating group, and simulative SD and Domperidone in the contrasting group. Treatment for14days. Observe patients of the general conditions, the three conventional, liver and kidney function, electrocardiogram, etc.Assess the two groups of disease curative effect, the curative effect of every symptom, and detect the SS and SP in the patients’serum by ELISASixteen eligible studies involvingResult:1.1466FD patients were included.The results of meta-analyses showed that SD could precisely improve the total effects more than the control group [OR=2.09,95%CI(1.56,2.79), P<0.00001]. The Security Analysis of the5literature suggest that Compared with the control group, The adverse reactions risk of simtang is lower than the control group,[OR=0.3,95%CI(0.16,0.54), P<0.0001]2.84cases were observed in this research among which4cases shed off,39cases in the treating group and41cases in the contrasting group. Before treatment,there were no significant differences in gender,age duration, and degree of illness,symptoms of traditional Chinese medicine total score, each symptom scores,the SS and SP in the patients’serum between the treating group and the contrasting group (P>0.05).3. After treatment:there were no significant differences in disease curaive effect and some symptoms (P>0.05), there were significant differences in total score of symptoms and another symptoms(P<0.05).4. SD can reduce the the content of ss and sp in the in the patients’ serum(P<0.05), but there were no significant differences between the treating group and the contrasting group (P>0.05).5. There were no significant differences in the shed off cases between the treating group and the contrasting groupConclusion: 1. Meta-analysis shows that SD canimprove the therapeutic effect on FD patients and have high security.2. SD have significant clinical curative effect on patients with functional dyspepsia with qi stagnancy of both liver and spleen.3. SD have better curative effect on some symptoms than Domperidone.4. SD can regulate the the content of ss and sp in the in the patients’serum, and it’s may be one of the possible mechanism to therapy FD.5. SD is safe and has no obvious side effects in clinical.