Study On The Serum Ghrelin And Obestatin And Psychologic Factor In Patients With Functional Dyspepsia

ObjectiveTo explore the serum Ghrelin and obestatin and psychologic factor in patientswith Functional dyspepsia, and further to explore the possible mechanism of FD,andgive the effective treatments on FD.MethodsSixty patients are diagnosed as FD and divided into two groups:one group ispostprandial distress syndrome(PDS) including thirty-five patients,the other group isepigastric pain syndrome (EPS) including twenty-five patiens Meanwhile,twenty-fivehealthy person were regarded as controls. Enzyme linked immunosorbent assay wasused to examine the level of serum Ghrelin (total, acylated ghrelin，desacyl ghrelin)and obestatin.We use Self-Rating Depression Scale(SDS) and Self-Rating AnxietyScale(SAS)and dyspepsia symptom scale to evaluate the condition ofanxiety,depression and dyspepsia symptom of FD patients. The results were beanalyzed by independent sample T Test, Oneway ANOVA,Spearman rank correlationrespectively.Results1.The level of serum Ghrelin(total) in group FD was significantly lower than thatin control(P<0.05).The level of serum Ghrelin (total)in PDS was significantly lowerthan in control and EPS(P<0.05).But no significant difference was found between thelevel of serum ghrelin(total) in group EPS and group control (P>0.05).2.The level of serum (acylated ghrelin) in group FD and group PDS weresignificantly lower than that in control(P<0.05). but no significant difference wasfound between the level of serum desacyl ghrelin among group FD, group PDS and group control (P>0.05). and no significant difference was found between the levelof both serum desacyl ghrelin and acylated ghrelin in group EPS and group control(P>0.05).3.The level of serum obestatin in group FD ang group PDS were significantlylower than that in control(P<0.05). But no significant difference was found betweenthe level of serum obestatin in group EPS and group control (P>0.05).4. In group FD,group PDS and group EPS,the SAS score,the SDS score weresignificantly higher than that in control (P<0.05).but no significant difference werefound between the group PDS and group EPS (P>0.05).5.In group FD,there were no significant correlations with the level of serumghrelin and the SAS score,the SDS score(P>0.05).there were significant negativecorrelations with the level of serum obestatin and the SAS score (P<0.05),but notSDS score.(P>0.05).6.In group FD,there were significant negative correlations with the level of theDyspepsia symptom scale and serum ghrelin (P<0.05). there were significant positivecorrelations with the Dyspepsia symptom Scale and the SAS score,the SDS score(P<0.05).Conclusion1.The alteration of serum Ghrelin(total, acylated)and obestatin may play apromotional role in the development of FD and PDS,but have no obvious relationwith EPS.2.Anxiety and depression may play promotional role in the development of FD,If add corresponding treatment,the patients would get better.3. The change of ghrelin may influence the state of subjective symptom of theFD patients...