An Analysis Of The Correlation Between Ghrelin Expression Levels And Mental Factors,Symptom Score In Patients With Functional Dyspepsia

Functional dyspepsia(FD)is a common disease of Gastroenterology,and has been valued by people recently years.Recent studies demonstrate that the incidence of FD is related to abnormal secretion of brain gut peptide.Ghrelin is a brain gut peptide molecule,which has a similar structure to motilin.This study was designed to explore the relationship between ghrelin and FD,and then provide a new theoretical basis for the diagnosis and treatment of FD.Objective:To investigate the difference between the expression of ghrelin in serum and gastric mucosa,Nepalese dyspepsia index(NDI)score,Self-rating Anxiety Scale(SAS)score and Self-rating Depression Scale(SDS)score in patients with functional dyspepsia and healthy people.And explore the correlation between the four factors in patients with functional dyspepsia.Methods:Thirty patients with functional dyspepsia and thirty healthy people were selected in Gastroenterology of Hebei General Hospital.Take NDI score,SAS score and SDS score.Collect fasting serum,collect mucosal specimen from the upper third of the gastric body.Serum ghrelin concentration was detected by ELISA.Detect the expression of ghrelin in gastric mucosa by IHC.Results:1 Serum ghrelin concentration and the ghrelin IOD of gastric mucosa in the FD group were lower than the control group(t=?4.81,Z=?6.51;P??<0.05).2 The score of SAS,SDS and Nepalese dyspepsia symptoms index(NDSI)in FD group was higher than those in control group(t=3.69,Z=3.47,t=10.42;P??<0.05).The score of Nepalese dyspepsia life quality index(NDLQI)in FD group was lower than the control group(t=?11.16;P<0.05).3 Serum ghrelin levels were negatively correlated with SAS score,SDS score and NDSI score in FD group(r=?0.852,?0.460,?0.929;P??<0.05),were positively correlated with NDLQI score in FD group(r=0.954;P<0.05).4 The ghrelin IOD of gastric mucosa was positively correlated with serum ghrelin levels,NDLQI score in FD group(r=0.599,0.547;P??<0.05),was negatively correlated with SAS score,SDS score and NDSI score in FD group(r=?0.586,?0.493,?0.580;P??<0.05).5 The score of SAS was positively correlated with the score of SDS,NDSI in FD group(r=0.577,0.778;P??<0.05),was negatively correlated with the score of NDLQI in FD group(r=?0.849;P<0.05).6 The score of SDS was positively correlated with the score of NDSI in FD group(r=0.405;P<0.05),was negatively correlated with the score of NDLQI in FD group(r=?0.473;P<0.05).Conclusions:1 Compared with the control group,the expression of ghrelin in the serum and gastric mucosa of FD patients was lower,and was negatively correlated with the symptom score,and was positively correlated with the quality of life score.2 Serum ghrelin concentration and gastric mucosal ghrelin level have the same trend of change in the patient with FD.We can indirectly measure the expression of ghrelin in gastric mucosa by measuring serum ghrelin concentration.3 Compared with the control group,anxiety and depression score of FD patients were higher,and were positively correlated with the symptom score,and were negatively correlated with the quality of life score.4 The levels of ghrelin in serum and gastric mucosa of FD patients were negatively correlated with anxiety and depression score.Anxiety and depression may affect the body's synthesis and secretion of ghrelin and thus cause the occurrence of FD.