The Effect Of Cinepazide Maleate On Cardiac Function And The Level Of NT-proBNP In Patients With Acute Myocardial Infarction

Objective: To observe the effect of cinepazide maleate injection on the levels ofserum NT-proBNP，myocardial enzyme and the cardiac function in patients with acutemyocardial infarction.Methods: From March，2009to June，2010，50patients with acute myocardialinfarction were enrolled in the study. The patients were received reperfusion bythrombolysis treatment in the department of cardiology medicine of ChenZhou No.1People’s hospital in Hunan province. All the patients enrolled were divided into thecontrol group and the Cinepazide Maleate group randomly，with25patients in eachgroup. The patients in the control group were treated with regular treatment followedby the guideline of acute myocardial infarction of China in2009（All patients weregiven with aspirin，clopidogrel，low molecular weight heparin and atorvastatin.Nitrates，tirofiban，angiotensin-converting enzyme inhibitor and β-blockers wereadded according to the disease）. The patients in the Cinepazide Maleate group wereadded with Cinepazide Maleate. Serums were taken from the patients at thein-hospital time，6h，15h，24h，3rd，5th and7th day after hospitalization. The levelsof NT-proBNP， myocardial enzyme and cTnI were tested. The cardiac functionwas observed by killip class at the in-hospital time，3rd，5th and7th day afterhospitalization. Left ventricular ejection fraction (LVEF) was observed by ultrasonicheart scan at the in-hospital time，3rd，5th and7th day after hospitalization.Result:1. The levels of serum NT-proBNP of patients in the control group and theCinepazide group have twin peaks，with one peak at15hours after hospitalization andanother at5th day after hospitalization. The levels of serum NT-proBNP at15hoursafter hospitalization were significantly higher than those at5th day afterhospitalization in each group. There was no significant difference of serum NT-proBNP between the two groups at the in-hospital time，6h and15h day afterhospitalization. The levels of serum NT-proBNP in the Cinepazide group weresignificantly lower than those in the control group at24h，3rd，5th and7th day afterhospitalization.2. The levels of serum CK-MB and cTnI of patients in the control group and theCinepazide group peaked at15hours after hospitalization and then decreasedgradually. There was no significant difference of serum CK-MB and cTnI between thetwo groups at the in-hospital time，6h and15h after hospitalization. The levels ofserum CK-MB and cTnI of patients in the Cinepazide group were significantly lowerthan those in the control group at24h，3rd，5th and7th day after hospitalization.3. The levels of serum Myo of patients in the two groups were at their peak at6hours after hospitalization and then decreased gradually. There was no significantdifference of serum Myo between the two groups at the in-hospital time and6h afterhospitalization. The levels of serum Myo of patients in the Cinepazide group weresignificantly lower than those in the control group at24h，3rd，5th and7th day afterhospitalization.4. There was no difference of the cardiac function with killip class between at3rd day after hospitalization and at the in-hospital time in the control group and theCinepazide group. The cardiac function of patients in the two groups was bettersignificantly at5th and7th day after hospitalization than that at in-hospital time. Thecardiac function of patients in the Cinepazide group was better than that in the controlgroup at5th and7th day after hospitalization.5. There was no difference of LVEF between at3rd day after hospitalization andat the in-hospital time in the control group and the Cinepazide group. LVEF in theCinepazide group was higher than that in the control group.6. Cinepazide can significantly decrease MACE in patient in1month after theincidence of AMI.7. At the in-hospital time and6h after hospitalization， the level of NT-proBNPin the Cinepazide group was positively correlated with that of CK-MB，cTnI in thecorresponding time. The level of NT-proBNP in the Cinepazide group was not correlated with cardiac function at the in-hospital time. It was positively correlatedwith cardiac function and negatively with LVEF at5th day after hospitalization.Conclusion:1. For patients with acute myocardial infarction and emergency thrombolysistreatment，cinepazide maleate added to basic treatment can abbreviate cardiac injury，decrease the level of NT-proBNP，improve cardiac function and decrease majoradverse cardiac events.2. The level of NT-proBNP values for the risk stratification of and prognosis inpatients with acute myocardial infarction.