The Resting State FMRI Study In NLE Patients And Correlation With Attention

Objective The resting state fMRI study in Non lesional epilepsy patients, using thealgorithm of low-frequency fluctuation observed amplitude increased and decreased inthe circumstances, in order to understand the patients resting state brain activity andabnormal brain regions in non-focal seizures in the role. Attention to functional testingof non-lesional epilepsy patients, in order to understand compromised of the patientsattention and the possible relationship between epilepsy patients with low-frequencyamplitude and attention functions.Methods (1)The low frequency fMRI were performed in non-lesional epilepsy groupand normal controls group in non-attention state,16cases with a history of more than2years, aged10-38years,frequent grand mal epilepsy patients. After pre-processing ofresting-state fMRI data,with which a whole-brain in low frequency fMRI fluctuationswas calculated to investigate the changes of the Low-frequency amplitude changes.(2)The above-mentioned16cases of non-lesional epilepsy patients and16normalcontrols were the Mini-Mental State Examination (MMSE) and test attention functionalbehavioral neuropsychological battery of tests (HKU-AHMU, BATTORY)（.3）Analysisthe attention functional changes that may exist between brain regions withlow-frequency amplitude of functional magnetic resonance imaging correlation.Results (1) Compared with normal subjects, the regions showing increased ALFF inNLE patients were distributed in right temporal lobe(15,-90,21)、medial frontal lobe（0,24,-24）、ventral anterior cingulate（-12,30,27）and the right cerebellar hemispher （-51,-57,-4）;(2) while the regions showing decreasedALFF covered the areas of theleft cerebellar hemispher(-48,-15,39)、 posterior cingulum gyrus(60,-21,33)andprecunens（-6,-54,66）;(3) NLE patients with three attention functional tests get lowscore compared with the normal group;(4) Balloons test and the Digital modalitiestest showed that the decline in sustained attention in NLE patients; the Stroop testshowed that the selected attention damaged with NLE patients.Conclusion (1) NLE patients shows abnormal brain functional organization inresting state．(2) The increased ALFF is considered the facilitation such as theepileptic activity generation and propagation;while the ALFF decreased is able toconsidered the function inhibition in these regions．(3) Long-term abnormal discharge ofattention function in non-lesional epilepsy patients with obvious damage.(4) Decline inthe ability of the sustained attention may be related to epilepsy patients with temporallobe and frontal lobe regions; a decline ability of selected attention, may be closelyrelated to the ventri anterior cingulated cortex damage..