The Correlation Between Different Blood Stasis Syndromes And Risk Factors Of Coronary Heatr Disease And Inflammation Indexes In Angina Pectoirs Patients

Objective: To analyse the distribution of different Blood Stasis Syndromes of AnginaPectoris, to explore the correlation between different Blood Stasis Syndromes of Anginapectoris and risk factors and inflammation indexes of Coronary Heart Disease and toinvestigate the difference between stable and unstable Angina pectoris.Method: One hundred and fifty patients of blood stasis syndromes of angina werecategorized into six groups based on the four examination methods of Chinese medicinesyndrome typing. They were cases of qi-deficiency blood stasis syndrome, phlegm blockedblood stasis syndrome, blood deficiency blood stasis syndrome, stagnant of qi blood stasissyndrome, toxic heat blood stasis syndrome and cold coagulation blood stasis syndrome.The clinical data of the patients were collected and the levels of high-sensitivity C-reactiveprotein (Hs-CRP), interleukin-6(IL-6) and lipoprotein-associated phospholipaseA2(Lp-PLA2) of the patients were measured, based on which the SPSS database were built.We first analyzed the basic information and syndromes and then conducted a logisticregression analysis of the correlation between syndromes and risk factors andinflammation index. At last, logistic regression analysis and multiple step-wise regressionanalysis were conducted on the correlation between the merger disease and syndromes andthe correlation between syndromes and inflammation indexes.Results: Among different syndromes of Angina Pectoris, the qi-deficiency bloodstasis syndrome, phlegm blocked blood stasis syndrome, blood deficiency blood stasissyndrome and stagnant of qi blood stasis syndrome are the most common ones. Theqi-deficiency blood stasis syndrome are correlated with the level of Lp-PLA2, the phlegmblocked blood stasis syndrome with BMI, the blood deficiency blood stasis syndrome with diabetes and the toxic heat blood stasis syndrome with smoking and BMI. The levels ofLDL、Hs-CRP、IL-6、Lp-PLA2in patients of unstable Angina pectoris are significantlyhigher than those in patients of stable Angina pectoris while the levels of HDL aresignificantly reduced. Hs-crp is positively related with IL-6. Lp-PLA2is positively relatedwith LDL while negatively related with HDL.Conclusion: There are internal relations between Blood Stasis Syndromes of AnginaPectoris and risk factors of Coronary Heart Disease. Inflammation factors and part of riskfactors are correlated. Lp-PLA2may cause the Coronary Heart Disease.