Integrative Treatment Of PCOS Clinical Research On The Effects Of IL-6, TNF-alpha

Objective: To study the IL-6, TNF-alpha and the pathogenesis of PCOS, combinedChinese and Western medicine treatment of PCOS, the impact study and to explore themechanism of action.Methods: Select Shandong Traditional Chinese Medicine University Hospitalgynecology clinicsyndrome is kidney yang in patients with PCOS (PCOS group)40cases,select thenormal menstrual pelvic B ultrasound without exception, no family history ofPCOS andother endocrine abnormalities of the health of women(normal group)20cases, atotal of60cases.2-4days in the menstrual cycle collected fasting venous blood todetermine IL-6and TNF-alpha level for statistical analysis. PCOS group were randomlydivided intotwo groups:20cases the menstruation the Yulin soup Jakarta England-35group (treatment group) and20cases of, Yougui capsule Jakarta English-35group (controlgroup). Both groups in the natural menstruation or withdrawal bleeding five days begantooral English-35and menstruation the Yulin soup or Yougui capsule is taken in sevendays, respectively, a total of three cycles. Before and after treatment were observedIL-6,TNF-alpha, Endocrine five, insulin, blood glucose level changes, clinical symptomsandsigns of change.Results:(1) The total effective rate was90.00%in the control group the totalefficiency of65.00%, the difference was significant (P <0.05); improve the TCM syndrome,pregnancy rate,and improve the acne, the treatment group and control groupdifferencesthere were significant (P <0.05). After treatment, the treatment group andcontrol group of bloodTNF-α、E2, of LH LH/FSH, INS and HOMA-IRdifference wassignificant (P <0.05).(2) Blood TNF-alpha values in the PCOS group than normal group of FSH, LH, BMI was positively correlated (P <0.05); IL-6levels in the PCOSgroup wassignificantly higher than the normal group, with BMI significant positivecorrelation (P<0.01).Conclusion: Menstruation Yulin soup joint Diane-35treatment of PCOS caneffectively improve theTCM syndromes and clinical symptoms, signs, reduce TNF-αvalues, adjust the level offemale reproductive endocrinology, and improve the pregnancyrate.