Relationship Between Polymorphism Of Estrogen Receptor-α Gene And Peak Bone Mass At Lumbar Vertebra In The Uygurs And Hans In Xinjiang Women

Objective: To investigate the association of estrogen receptor-α gene with peak bonemineral density at lumbar vertebra in the Uygurs and Hans in Urumqi women. Methods：The XbaI and PvuⅡ genotypes of ER-αwere determined by PCR-RFLP in135Uygursand160hans unrelated healty women aged20-40years in Urumqi.Bone mineral density(BMD) was measured by QCT bone densitometry. Serum Ca,Pand AKP level weremeasured by ELIASA. Results: Hardy-Weinberg Equilbrium was evident for ER-αgenepolymorphism in the Uygurs and Hans. There was significant difference in PvuⅡandXbaI polymorphisms between the Uygurs and the Hans.Only a significant association wasfound between PvuⅡ genotype and BMD at L2-4in the Uygurs（P＜0.05）,the bone massof Uygurs with Pp/pp genotype was lower than that of PP genotype at lumbar vertebr（aP＜0.05）. Conclusion: The XbaI polymorphism of ER-αgene seem not potentiallyinfluence on peak bone mass in the Uygurs and the Hans women.The attainment andmaintenance of peak bone mass at lumbar vertebra had associated with PvuⅡpolymorpis-m in the Uygurs.