Clinical Analysis Of193Cases Of Acute Organophosphate Poisoning

Objective:To investigate the risk factors of respiratory failure, heart failure of acute organophosphorus pesticide poisoning(AOPP) and the factors of severe AOPP with elevated serum amylase.Methods:(1)193AOPP cases were divided by the poison species, toxicity and poisoning degree,then study the statistical difference of respiratory failure, heart failure among each group.(2) Patients were divided into respiratory failure group and non-respiratory failure group, heart failure group and non-heart failure group, then study the relationship between serum cholinesterase (CHE) within24hours and respiratory failure, heart failure.(3) There are18cases with elevated serum amylase in120cases of severe poisoning patients, the logistic regression method was used to study the risk factors of elevated serum amylase.Results:(1) The effects of poison species and toxicity on patients’ respiratory failure, heart failure were not statistically significant (P>0.05);There was no statistically significant differences between mild poisoning and moderate poisoning on respiratory failure and heart failure,while that of the other two groups were statistically significant (P<0.01).(2) Serum CHE in respiratory failure group and the heart failure group was significantly lower than that of the non-respiratory failure group and the non-heart failure group, and the difference was significant (P<0.01).(3) There was a certain relevance between the dichlorvos poisoning、the serum CHE levels within24hours and the serum amylase levels.Conclusion:The degree of toxication and serum CHE levels can be used as predictors which can help to forecast the occurrence of respiratory failure、 heart failure; Compared with other poisons,dichlorvos was more likely to cause an elevated serum amylase among severe AOPP patients; Lower serum CHE levels was a risk factor of the AOPP patients who had an elevated serum amylase.