Real-Time Three-Dimensional Echoc-radiography Et Al Assessment Of Co-ronary Artery Bypass Graft And Mes-enchymal Stem Cells For Treating Ischemic Heart Disease

ObjectiveReal-time three-dimensional echocardiography(RT-3DE) and tissuemovement quantitate advance (TMQA) investigated the change of leftventricular heart function of patients with ischemic heart disease before andafter off-pump coronary artery bypass graft (OPCABG) meanwhile injectingautologous mesenchymal stem cells (MSCs).MethodsDate of normal control (group A)30patients,OPCABG group (group B)30patients and OPCABG+MSCs group(group C)27patients were acquired byRT-3DE and TMQA tech-nology before and after operation one month, threemonths, six months and one year. The left ventricular global and regional enddiastolic volume(EDV),end systolic volume(ESV),ejection fraction(EF), globalpeak ejection rate (gPER) and global peak rapid filling rate(gPRFR) wereobtained.ResultsBefore operation, Group B and C’s global and regional heart function weresignificantly lower than group A’s(P<0.01) and there was no significantdifference between group B and C (P>0.05). There was no obvious imp-rovement of left ventricular global and regional heart function in group B and Cafter OPCABG one month(P>0.05). After three months two group’s heartfunction were better than before OPCABG and after one month(P<0.05). Heart function significantly raised after six months than before OPCABG, after onemonth and three months(P<0.01，P<0.05). Left ventricular global and regionalheart function after OPCABG one year and six months were no evidentdifference in two groups. Comparing group B and C after operation differenttime, group C was a little better than group B, but there was no evidentdifference (p>0.05). After six months, Group B and C’s global heart functionapproached the normal level nearly (p>0.05), regional heart function were lowerthan Group A (P<0.05).ConclusionsOPCABG meanwhile inject autologous mesenchymal stem cells and onlyOPCABG all could obviously improve the heart function in IHD patients, thefront (group C) slightly better than behind (group B).RT-3DE and TMQA couldquantitatively evaluate the change of left ventricular global and regional heartfunction before and after OPCABG meanwhile MSCs in different time．...