Research Of Serum8-iso-prostaglandin-F2α Level And Related Risk Factors Of Progressive Ischemic Stroke

Background and Objectives: Progressive ischemic stroke (PIS), as a major subtypesof ischemic stroke (IS), received extensive attention of scholars at home and abroad onaccount of high disability rates and mortality rates. A number of studies have shown:hypertension, diabetes, atherosclerosis and inflammatory factors are related, but the researchof process of oxidative damage in PIS develops slowly at home and abroad. This paperdiscussed the relationship between oxidative damage and the occurrence and development ofPIS, at the same time, the relations between PIS and common risk factors of cerebrovasculardisease were analyzed.Methods:We selected67PIS patients who were hospitalized in the neurologydepartment of first hospital Jilin University from January of2012to January of2013as PISgroup, and randomly choosed81IS patients bur not PIS patients who were hospitalized atthe same time in this hospital as non-PIS group.We also randomly selected32healthy peoplefrom the medical examination center as healthy group.We analyzed the level of8-iso-PGF2αbetween three groups, and also analyzed and compared the age, gender, smoking,hypertension, diabetes, high blood lipids, arterial stenosis and other factors between the PISgroup and no-PIS group. At the same time, the relations between8-iso-PGF2α andhypertension, diabetes, high blood lipids, the degree of arterial stenosis were analyzed.Results:(1) There are no significant differences between PIS group and non-PIS groupin gender and age.(2) We analyzed the progress occured in PIS group, most of PIS occurwithin7d, after7d less.(3) Risk factors between PIS group and non-PIS group: Single factoranalysis showed: There are significant differents between PIS group and non-PIS group indiabetes, hypertension, vascular stenosis degree and the systolic pressure and diastolicpressure(P<0.05). Among these results, the rate of people who are attacked by hypertensionand diabetes mellitus in PIS group is higher than those in non PIS group; The PIS incidenceincreased with the degree of stenosis increased; The SBP and DBP level of PIS group’sadmisson is under the non-PIS group.(4) Multiple Logistic regression analysis showed:systolic pressure decreased and the increase of the level of8-iso-PGF2α are independent riskfactors of PIS, and negative correlation with systolic pressure, positive correlation with the level of8-iso-PGF2α.(5) There are no significant differences between PIS group andnon-PIS group in smoking, blood lipids, fibrinogen(P>0.05).Conclusions:(1) Systolic pressure decreased and the increase of the level of8-iso-PGF2α are independent risk factors of PIS; hypertension, diabetes, vascular stenosisare non independent risk factors;(2) The serum8-iso-PGF2α level, as a sensitive index, canbe used for evaluating IS oxidative damage of brain tissue, oxidative damage of PIS group ismore severe than non-PIS group;(3) The serum8-iso-PGF2α level have relations withhypertension, diabetes, coronary stenosis, but not with lipid components and vascularstenosis number;(4) Administration of antioxidant and expansion (blood pressure belownormal levels) therapy in the acute phase of IS have important significance.