Effect Of Dezocine On Convalescence After Gynecological Laparoscopic Surgery

Objection：To observe the efficacy and security of dezocine after gynecologicallaparoscopic surgery.Methods：Between November2011and June2012, the patients who underwentlaparoscopic hysteromyoma, ovary removal surgery and subtotal hysterectomy fromDepartment of Obstetrics and Gynaecology of Second Hospital of Jilin Universitywere selected. Total60patients were left after the inclusion and exclusion criteriascreening, who were randomly divided into two groups which were dezocine groupand fentanyl group. Both of two groups received the same preanesthetic preparation,anesthetic induction and anesthetic maintenance. Patients of dezocine and fentanylgroups were administered intravenously drug5min before the end of surgery. Thedoses were0.1mg/kg and1.5μg/kg for dezocine and fentanyl groups respectively.Heart rate (HR), non-invasive blood pressure (NIBP), end-tidal partial pressure ofcarbon dioxide (SpO2), oxyhemoglobin saturation by pulse oximetry (PETCO2),electrocardiograph (ECG) and bispectral index (BIS) were monitored continuouslyduring the surgery. The time between drug withdrawal and extubation and the timeof staying at postanesthesia care unit (PACU) were recorded. Within12h afterarriving at PACU, the Ramsay, VAS and BCS scores were assessed in1h,3h,6hand12h. Incidence and severity of adverse reactions such as nausea and vomiting,sleepiness, itchy skin and respiratory depression were recorded within6h aftersurgery. The results were analyzed with statistical analysis software between twogroups.Results：There was no significant difference between dizocine group andfentanyl group in the patient general characteristics and duration of surgery (P＞0.05). But there were significant differences in the time between drug withdrawaland extubation and the time of staying at PACU(P＜0.05). The VAS, BCS and Ramsay scores in dezocine group were lower than those in fentanyl group(P＞0.05).The incidence of nausea and vomiting within6h after surgery in dezocine group waslower than that in fentanyl group and there were significant differences between thetwo groups (P＜0.05). There was no significant difference between the two groups inthe incidence of sleepiness within6h after surgery(P＞0.05), which in dezocinegroup was lower than that in fentanyl group. There was no other adverse reactionhappened within6h after operation between two groups.Conclusion：1. It is effective that0.1mg/kg dezocine or1.5μg/kg fentanyl are administeredintravenously5min before the end of surgery after gynecological laparoscopicsurgery.2. The times of postoperation recovery and extubation in dizocine group wereshorter than those in fentanyl group.3. Incidence of adverse reactions of dezocine is lower than fentanyl.In consequence, dizocine applied to gynecological laparoscopic surgery is safe.