Combined Detection Of Serum CA242, CA19-9in Gastric Cancer Pathology And Prognosis Of Application

Background:Gastric cancer is a common malignant tumor all over the world. The early diagnosis of gastric cancer, the efficacy of monitoring and recurrence monitoring is the key to effective treatment, which depends on the accurate detection of the gastric tumor marker. But less significance of combined detection of serum CA242, CA199,CA242, CA199detection in gastric cancer pathology and prognosis for comparative analysis.Objective:To investigate the combined detection of serum tumor marker CA242, CA19-9in gastric cancer pathology and prognosis analysis applications.Methods:Retrospective analysis from February2002to March2008period Shandong University Qilu Hospital admitted191cases patients with gastrointestinal cancer. All cases conform to inclusion criteria. CA242, CA19-9positive results are divided into groups negative and positive tumor markers.Comparative analysis of each group of patients with gastric cancer age, sex, tumor size, tumor differentiation type (G), depth of invasion (T), lymph node involvement (N), clinical stage (TNM staging), vascular metastasis, distant metastasis, factors such as postoperative chemotherapy and prognosis for analysis.Results:The age and sex of the serum tumor marker substance CA242, CA199positive or not had no effect (P>0.05). This paper mainly discusses the level of serum CA242, CA242high differentiated and poorly differentiated patients with positive rates were26.32%,18.38%, and no significant difference between the two groups,(x2=1.16, P>0.05).The degree of malignancy of tumor and the depth of tumor invasion was no significant correlation (P>0.05). Lymph node metastasis and without lymph node metastasis CA242positive rates were20.69%,17.65%, both of which also no significant correlation (x2=0.83, P>0.05). Single CA242may not be able to assess the depth of tumor invasion, the degree of malignancy of lymph node metastasis. CA242and CA199-positive gastric cancer patients with stage â…£ and â…¢ and patients with phase â… ,â…¡ were compared.There is a significant difference (P <0.05). Indicate CA199, CA242elevated levels of diagnostic yield with the TNM staging of gastric cancer increased with the rising, especially in stage â…£ and liver metastasis group was the most obvious conclusion is consistent. CA242in CA199positive gastric cancer late stage of disease more likely.CA199expression of CA242in patients with gastric cancer risk factors, indicating that both the expression of the risk factors affecting the survival time of gastric cancer.CONCLUSIONS:CA199, CA242increased level diagnostic yield with gastric cancer TNM staging increment increased, especially in stage â…£ and liver metastasis is the most obvious. CA242and CA199positive patients with gastric cancer tumor volume greater; deeper depth of invasion, more invasion of or invasion of serosa; higher rate of positive lymph nodes, the transfer of more severe. And a worse prognosis, survival was significantly shorter. Detection of serum CA199and CA242levels contribute to the clinical staging of gastric cancer, but also as a new experimental metastasis of gastric cancer diagnostic indicators, and can be a rough estimate of the prognosis of the patients may.