The Clinical Research Of Three-Dimensional Color Power Angiography On Diagnosis Of Diabetic Nephropathy

Objective This paper aimed to explore the clinical value of using three-dimensional color power angiography (3D-CPA) to evaluate the renal blood perfusion in patients with diabetes mellitus and then to diagnose diabetic nephropathy (DN) early.Methods In the study, twenty healthy adults serving as control group and sixty patients with type2diabetes mellitus were enrolled. The sixty patients were classified into three groups according to their24-hour urinary albumin excretion (24hUAE), and each group contained twenty patients. Group I,24hUAE<30mg, at normal proteinuria stage; group II,24hUAE at30-300mg, at early DN stage; group III:24hUAE>300mg, at clinical DN stage. In each subject, the renal blood perfusion was observed through3D-CPA and vascularization index (VI), flow index (FI) and vascularization flow index (VFI) were measured with3D-CPA. The parameters above were all the average of the two kidneys’. The differences among data of different groups were analyzed by the statistical software SPSS for windows17.0.Results The blood flow gradation was4-5levels in normal control group and0-4levels in patients with diabetes mellitus. Among three groups of patients, with the aggravation of diabetes mellitus renal damage, the renal blood perfusion reduced. VI, FI and VFI reduced in all three groups of patients with diabetes mellitus, compared respectively with those of the normal control group. That difference was of statistical significance. Among three groups of patients with diabetes mellitus, with the progression of DN, VI, FI and VFI trended to decrease gradually. That difference was of statistical significance.Conclusion3D-CPA could display the three-dimensional structure of renal vessels intuitively, really and integrally, could prompt the trend that DN microangiopathy involved progressively from the distal peripheral blood vessels to the proximal trunk, and could semi-quantitatively evaluate the renal blood perfusion condition of DN in morphology.3D-CPA blood flow parameters (VI. FI and VFI) could help find renal dysfunction of patients with DN early and sensitively and provided a new method for noninvasive clinical evaluation of DN renal hemodynamic changes.