| BackgroundCardiorenal syndrome receives much concern in recent years. The latest definition of CRS was "a pathophysiologic disorder of the heart and kidneys whereby acute or chronic dysfunction of1organ may induce acute or chronic dysfunction of the other". The pathologic mechanism of CRS is very complicated. It’s a difficult and complicated diseases in clinical work. According to the different pathogenesis characteristics, the CRS was divided into five types. The data of clinical epidemiologic investigation and therapy methods is still limited. The main pathologic mechanism of CRS were hemodynamic changes, inflammatory response, over-activation of RAAS, activation of sympathetic nervous, NO-ROS imbalance, anemia and iron deficiency and so on. They interacte and promote each other. A vicious circle will formate in final. The current project will make a deep research on the role of inflammatory response in cardiorenal syndrome. The results show that elevated serum total cholesterol or LDL cholesterol is an independent risk factor for coronary heart disease and ischemic stroke. So, we must give attention to early prevention and treatment of dyslipidemia. But China’s current lipid control compliance rate is still less than30%. There is a long way to prevent and control hyperlipidemia. Many studies have found that promoting blood circulation therapy(Xuefuzhuyutang as the representative) can get significant effect in treatment of heart and kidney disease, and it can effectively reduce blood lipid levels.ObjectiveIn this study, the main object is to clear the change of heart anf kidney function, and the inflammatory factors expression in kidney injury. The main indicator are ICAM-1and NF-κB. To explore the intervention effect of promoting blood circulation therapy. Provide methods and clues for basic research and prevention countermeasures in CRS.MethodsAccording to the methods in literaries, we lagated the LAD to make the mode of myocardial ischemia. Animals was divited into normal control group, normal control sham operation group, high-fat control group, Fat sham surgery group, Model group, Xuefuzhuyu five times group, Xuefuzhuyu ten times group,8rats in each group. Before drawing materials, all the rats received feeding for14days. And then, we check the ECG, blood and urine biochemistry, Inflammatory Factors in Blood serum, the nephrotic management histological changes and metabolomics changes of the kidney.Results1.The positive rate of ischemic ECG decreased after the therapy of promoting blood circulation and removing blood stasis;2.The serum creatinine increased and creatinine clearance rate (Ccr) declined after MI in hyperlipidemia rats(P<0.05);3.The serum level of ICAM-1,IL-6increased after the MI(P<0.01);4. After the therapy of promoting blood circulation and removing blood stasis, we can observe the downward trend of serum creatinine and the upward trend of Ccr, but no significant difference(P>0.05). At the same time, the serum level of ICAM-1,IL-6slightly lower than model group, but no significant difference(P>0.05). ConclusionKidney injuey could be observed after myocardial ischemia in hyperlipidemia rats, and the expression of inflammatory factors was increased. Promoting blood circulation therapy could reduce the degree of renal impairment caused by myocardial ischemia and reduce the level of TC and LDL-C. |
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