| Background:Malignant bone tumor is a disease of serious harm to human health and life, especially the majority of malignant bone tumors occur in adolescents population, poor treatment, in order to make the study of bone tumors to become one of the focus of attention of the medical field. China’s traditional medicine has a unique theory in anti-tumor treatment. Natural medicine but also for its wide range of efficacy, precise, low toxicity, wide range of domestic and international concern. At present, the anti-tumor active ingredient extracted from traditional Chinese medicine is also increasingly receive attention, which is mostly plant extracts. Experiments and clinical studies of anti-tumor effect of Chinese medicines, there are also reported single herb and compound in the affirmation of effect of anti-tumor, based on the affirmation of traditional Chinese medicine in cancer therapy, combined with modern medicine, immune function in tumor an important role in experimental studies provide strong theoretical basis for the clinical treatment of bone tumors, bone tumors will also be of great significance.Objective:Based on the theory of traditional Chinese medicine in cancer therapy,"the rousing" observed "uphold" traditional Chinese medicine (Renshen, Maidong,Congrong) differences in cellular immunity and humoral immunity of tumor-bearing mice using to promote cellular immunityrole in enhancing the capacity and resistance of human tumor suppressor; promote their application in infectious diseases through its impact on humoral immunity, while avoiding to aggravate or cause tumors to spread and side effects have important significance for improving the clinical efficacy. And the same drug at the same time observe the different reactions and differences in the role of cellular immunity and humoral immunity, in order to guide the correct application of these drugs in cancer patientsMethods:The mice were randomly grouped into blank group, the tumor control group, experimental group, the tumor control group, experimental group made solid tumors, tumor-bearing mouse model, low in proportion to the high power amount gavage medicine (Radix, Ginseng, Cistanche)mice and mice mortality observed after2weeks, eye blood was collected and centrifuged to obtain serum, Elissa kit measured cellular immune CD4, CD8and humoral immune C3,C4, and immunoglobulin in the blood were sacrificed aftermouse anatomical entity measuring tumor diameter, to calculate the inhibition rate.Results:Radix, Ginseng, Cistanche SL80growth of tumor cells was significantly inhibited:Compared with the tumor control group, low and high level groups in mortality S180-bearing mice, testing of Chinese medicine are lower than the mortality rate of tumor control group. S180ascites tumor cell inoculation, and during the observation period, in addition to the normal group, the poor in the other groups In general, the tumor control group, the phenomenon of hair removal, traditional Chinese medicine dose group showed mild; Chinese medicine Ophiopogon ginseng low high-powered three the group and Cistanche low high-power amount of the average tumor diameter was significantly lower than the tumor control group (P<0.01), Radix ginseng, Cistanche SL80tumor Cell growth was significantly inhibited, and with the gavage the amount of increase in the inhibitory effect also increased; can significantly improve the cellular immunity, reduce humoral immunity is not obvious.Conclusions:Uphold traditional Chinese medicine to reduce the tumor relative damage to the body, so that the body showed a better tolerability, and improve the quality of life; significantly inhibited tumor growth of S180-bearing animals, the immune organs of the tumor-bearing mice have a certainprotection and the inhibition rate also increased with increasing dose; significantly improved the immune function of tumor-bearing mice cells, reduce the tumor-bearing mice humoral immunity is not obvious, can regulate the tumor microenvironment. |
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