For Functional Constipation Of Chinese Medicine Compound Screening And Research

Purpose:With "the universal party" database management system "and contemporary treatment functional constipation and related disorders of literature review and analysis, based on the principle with French medicine organic combination principle, through the experimental research of traditional Chinese medicine treatment were functional constipation small compound to serve the clinical and Chinese herbal medicine new medicine developed.Materials and methods:1. With "the universal party" database management system and the modern literature review and analysis of, grasp the syndrome differentiation and treatment of functional constipation drug laws, and screened functional constipation effective treatment of traditional Chinese medicine small compound-Qingchang particles2. Use pharmacology experiment methods validation Qingchang particles on experimental functional constipation influence. Qingchang particles low, medium and high (born in drug,13,26g project,6.5kg-1·d-1) dose group, rhubarb aperient particles (3.12g·kg-1·d-1) group, polyethylene glycol (peg)4000powder (5.2g·kg-1·d-1) group. Ig every day to medicine1, the continuous5d. Through the Qingchang grain to mice quantity and time, and im defecate volume, small intestine propulsion and other sports (defecate experiment, and im volume at the end of the experiment, the carbon of experimental) role and influence, investigation Qingchang particles on experimental functional constipation effect. Data are used for Windows software package SPSS15.0statistical processing, each data results to±s said, between the group of variance analysis method with LSD multiple comparison, P<0.05with a statistical significance.Fruit:1. Dry and water loss model group, and Qingchang particles low, medium and high doses of mice first time and4h inside bowel row and points for black respectively175.5+/-31.2min and4.6+/-3.0) grain,(141.9+/-39.9min and5.5+/-3.7) grain,(113.1+/-39.3min and9.1+/-2.4) grain,(80.8+/-28.7min and12.2+/-1.7) grain, compared with model control group in, high dose group of defecate time is shortened, defecate number increased (P<0.01).2. The blank group, Qingchang particles low, medium and high dose group respectively bowel weight(1.67+/-0.12g,(1.79+/-0.14g,(1.84+/-0.13g,(1.86+/-0.25g, Qingchang particle group compared with blank bowel significantly increased the weight of each (P<0.05, P<0.01).3. Intestinal dynamic obstacles model group, and Qingchang particles low, medium and high doses of mice first time and4h inside bowel row and points for black respectively (170+33.1) the min and4.2+/-2.3) grain,(128.8+/-43.8min and6.6+/-2.1) grain,(101.7+/-8.4min and8.4+/-1.7) grain,(86.5+/-24.9min and (11.5+/-2.5grains and model control group more obvious time is shortened, defecate number respectively increased (P<0.05, P<0.01).4. Carbon ink respectively advance distance (35.2+/-7.2cm,43.2+/-4.7cm,42.5+/-5.6cm,46.8+/-6.2cm, and blank compared obvious had long each (P <0.05, P<0.01).5. Blank group, Qingchang particles low, medium and high doses of mice first time and4h inside bowel row and points for black respectively137.2+/-42.4min and6.7+/-2.9) grain,(98.7+/-57.6min and10.5+/-6.4) grain,(81.3+/-61.8min and11.0+/-5.2) grain,(69.1+/-27.6min and11.8+/2.9) grain, and blank compared time is shortened, defecate number respectively increased (P<0.05, P<0.01).Theory:1. Literature theory researchAccording to the ancient and modern medicine and clinical syndrome differentiation rules, you can make sure that functional constipation by a thermal secret in the majority. In view of the rich rhubarb anthraquinone long-term use of the disadvantages of, abandon contains anthraquinones diarrhea case, from the hot secret legislation prescription. Based on this idea, with the universal party "database management system, and screened by gardenia, c. deserticola and synephrine of heat treatment of the secret of the Chinese medicine small compound. The party not such as the extreme rhubarb attack is tasted, with spilled hot runchang to use, can overcome rhubarb, adverse reactions.2. Experimental study2.1Qingchang particles can obviously accelerate bowel mice;2.2Qingchang particles can significantly reduce mice intestine to water absorption;2.3Qingchang particles can increase the mice bowel volume;2.4Qingchang particles can enhance the normal mice peristalsis;2.5Qingchang particles can promote mice and small intestine motional movement.