Different Tcm Syndrome Stage Peripheral Immune Depression T Lymphocyte Subgroup And Its Correlation With Single Amine Neurotransmitter Of Clinical Research

Objective:to observe the Basic information such as gender, age, syndromes of the geriatric depression, peripheral blood T lymphocyte subsets and monoamine neurotransmitter levels in patients with different stages of depression symptoms, so as to understand the characteristics of the geriatric depression, the various syndromes stage variation of T lymphocyte subsets the correlation of Monoamine neurotransmitters and T lymphocyte subsets.Methods:With A case-control study method, we observed a total of150cases in elderly patients with depression, which inclund19cases of the empirical group-19patients in sydrome of liver-qi stagnation;52cases of the deficiency mixed group-21patients in Liver depression and Spleen,31patients in Liver stagnation and phlegm retention;79cases of the deficiency syndrome group-11patients in deficiency of heart and spleen syndrome,68patients in disharmony of heart and kidney.50normal elderly were compared and analyzed. We Observed the differences of peripheral blood T lymphocyte subsets-CD3, CD4, CD8and CD4/CD8in different syndromes and symptom stages,as well as the correlation of Monoamine neurotransmitters and T lymphocyte subsets. We used SPSS17.0statistical software for statistical analysis.Results:(1)The proportion of men and women is1:3.65in elderly patients with depression, women were significantly higher than men, the difference was statistically significant (P<0.01);(2)Different stage patients with depression syndrome with course of disease have difference(P<0.01), the various stratified by age TCM proportion of the waiting stage (P<0.01);(3)The different syndromes percentage of elderly patients with depression were:liver Qi stagnation occupied12.7%, Liver depression and Spleen occupied14%, Liver stagnation and phlegm retention occupied20.7%deficiency of heart and spleen syndrome occupied7.3%, disharmony of heart and kidney occupied45.3%, the difference was statistically significant (P<0.05);(4) The different symptom stages percentage of elderly patients with depression were:12.7%of the empirical group deficiency mixed group of34.7%and52.6%deficiency group difference was statistically significant (P<0.05);(5) The CD3in patient group reduced compared with the normal control group (P<0.05), the CD4slightly higher than the normal control group, but the difference was not statistically significant (P>0.05). the CD8significantly reduced compared with the normal control group(P<0.01), the CD4/CD8increased significantly compared with the normal control group (P<0.01)(6) The level of peripheral blood T lymphocyte in patients of different symptom stages were different.The comparison of CD3between different syndrome stages in patients,even the comparison of CD3between different syndrome stages and the normal control group:the CD3in deficiency mixed group was lower than the normal control group, the difference was statistically significant (P<0.05);The comparison of CD8between different syndrome stages in patients,even the comparison of CD8between different syndrome stages and the normal control group:the CD8in empirical groups was lower than the normal control group, the difference was statistically significant (P<0.05); the CD8in deficiency mixed group and deficiency group were significantly lower than the normal control group, the difference was statistically significant (P<0.01);The comparison of CD4/CD8between different syndrome stages in patients,even the comparison of CD4/CD8between different syndrome stages and the normal control group: the CD4/CD8in deficiency mixed group and the deficiency group were significantly higher than the normal control group, the difference was statistically significant (P<0.01); the CD4/CD8in empirical group and the deficiency group were lower than the deficiency mixed group, the difference was statistically significant (P<0.05).(7) The correlation between5-HT and T lymphocyte subsets:the5-HT in patient was related with the CD8, CD4/CD8of T lymphocyte subsets (P<0.01, P<0.05);(8) The correlation between DA and T lymphocyte subsets:the DA in patient was related with the CD8, CD4/CD8of T lymphocyte subsets (P<0.01, P<0.05).(9) The correlation between NE and T lymphocyte subsets:no correlation was found between NE and T lymphocyte subsets(P>0.05).Conclusion:Elderly patients with depression is in female-dominated; the patient’s condition was gradually worsening trend with age;the main syndrome type were Liver stagnation and phlegm retention and disharmony of heart and kidney;the main syndrome stage were deficiency mixed group and deficiency group; patient’s immune function changed a lot with the normal control group, there is a significant change with patient’s immune function,who is in deficiency mixed group or deficiency group. neurotransmitters was related with immune function, mainly between neurotransmitters and CD8, CD4/CD8.