Effect Of Preemptive Analgesia With Flurbiprofen Axetil Joint Dezocine On Abdominal Surgery Effect Of Postoperative Pain

Objictive: Study of dezocine and flurbiprofen axetil combined with preemptiveanalgesia on gastrointestinal tumor operation postoperative analgesic effects.Methods: The subjects were eighty ASA I-II patients at the age of35to65undergoingelective gastrointestinal neoplasm operations during the period from August2011toSeptember2012in Yan’an University Affiliated Hospital.The patients were randomlyallocated to four groups with20cases each,who received postoperative patient controlledintravenous analgesia(PCIA) with fentanyl0.2ug/ml.h and butorphanol tartrate0.003mg/kg.h in100ml normal saline. Group D was injected dezocine0.1mg/kg beforeanesthesia induction;Group F wan injiected flurbiprofen axetil1mg/kg before anesthesiainduction;Group DF wan injected dezocine0.05mg/kg and flurbiprofen axetil0.5mg/kgbefore anesthesia induction;Control group was injected the same volume of physiologicalsaline before anesthesia induction.All patients open center vein and monitor routinely ofblood pressure,heart rate,pulse,blood oxygen saturation after entering the operatingroom.All patients used tracheal intubation general anesthesia and respiratory controldownlink operation and injected atropin0.5mg with intravenous before anesthesia firstthirty minutes.All suffers adopt anesthesia induction followed by midazolam0.05mg/kg,fentanyl4ug/kg,propofol1.5mg and rocuronium0.6mg/kg.At theoperation,using propofol3-5mg/kg.h,remifentanil0.3-0.5mg/kg.min,benzene sulfonicacid3-4mg/kg.h and sevoflurane1.5%-2%to maintain the anesthesia. After theoperation,all patients got into the anesthesia recovery room and awake extubation afterpostoperative analgesia pump(PCIA). Observing blood pressure,heart rate,pulse,bloodoxygen saturation of all patients at4h,6h,12h after remanding ward. The postoperativesituation was evaluated by VAS scoring,Ramasy scoring,agitated scoring and side effects were recorded at4,6,12and24h after operation and pressing times in24h afteroperation.Results:1.No significant difference in age, gender, weight, ASA grading and operation timeduring the surgery among four groups.2.The VAS scores at4,6h after operation were higher in control group than in groupD,group F and group DF(p<0.05).The VAS scores at4,6h after operation were less ingroup DF than in group D and group F(p<0.05).There were no significant diffierences inthe VAS scores at12,24h in four groups after operation.The VAS scores at4,6h ingroup D and group F have no significiant differences.3.The pressing times in24h were more in control group than in group D,group F andgroup DF(P<0.05).4.Ramsay sedation score (RSS) in four groups at each time were all satisfying withoutsignificant difference (P>0.05).5.No significant difference in restless score in four groups at each time.6.Postoperative4h,6h,12h in four groups of patients with blood pressure,heartrate,pulse,blood oxygen saturation had no significant differernces.7.There were no significant diffierences in the incident of side effects.Conclusion Preemptive analgesia with flurbiprofen axetil combined dezocine canenhance postoperative analgesia and relief postoperative pain.The effect is better thanusing flurbiprofen and dezocin alone.