Lp-PLA2Has Relation With Atherosclerosis Cerebral Infarction And Carotid Atherosclerosis Plaque

Objective:Ischemic stroke is a common disease at present, the elderly, in today’s world with a high rate of morbidity, disability and mortality, their serious impact on people’s health, well-being and life. In atherosclerotic cerebral infarction in acute ischemic stroke is the most common type. Has now confirmed that chronic inflammation in atherosclerosis development plays a very important role in the process. Local thickening of arterial intimal basic damage are formed of atherosclerosis and unstable atherosclerotic plaque rupture causes is an important cause of ischemic stroke. The latest study found that lipoprotein-associated phospholipase A2(lipoprotein-associated phospholipase A2,LP-PLA2) may be a new inflammatory response markers, and is closely related to atherosclerosis. This study focused on serum lipoprotein-associated phospholipase A2and atherosclerotic cerebral infarction and carotid arteriosclerosis plaques.Methods:Clinical select January2012to October2012in Shanxi Medical University second hospital neural within Ⅱ section Hospital of ACI patients75cases for case Group (n=75cases), while period from this homes outpatient or ward in the Select age, and gender and case group phase match of by try who65cases for against group (n=65cases), all per capita accept plasma LP-PLA2activity, and high sensitivity c reaction protein (hs-CRP), and total cholesterol (total cholesyerol TC), and Three acyl glycerol (triglyceride TG), low density lipoprotein (low density lipoprotein LDL), high-density lipoprotein (high density lipoprotein HDL), quantitative determination of plasma Fibrinogen (FIB) level of determination, and compared to each other; while bombarded with questions about age, gender, body mass index, hypertension, history of diabetes, smoking, alcohol consumption and other risk factors for cerebrovascular disease. ELISE method for determination of serum concentration of LP-PLA2in.Results: 1.the ACI group and the control group age, sex, body mass index, smoking history, no statistically significant difference in the incidence of drinking history (P>0.05).2.the ACI group and the control group incidence of hypertension, diabetes mellitus was higher than the control group (P<0.05).3.the ACI group LP-PLA2, andhs-CRP, andLDL, andTG, andTC levels were significantly higher than the control group, differences are statistically significant (P<0.05).4.the ACI group HDL levels significantly lower than the control group, differences are statistically significant (P<0.01).5.the ACI group and the control group Fib level difference not statistically significant (p>0.05)。6.different sets of plaque of carotid atherosclerosis plaque in the Crouse points higherLP-PLA2higher levels.Conclusion:1.LP-PLA2can be used as one of the independent risk factor for atherosclerotic cerebral infarction, certain value to predict atherosclerosis cerebral infarction.2.By detecting indirect understanding of the extent of carotid atherosclerosis in LP-PLA2concentrations.