An Efficacy And Safety Study On Atomoxetine Hydrochloride Which Was Used To Treat Children With Attention Deficit Hyperactivity Disorder

Objective:To evaluate the efficacy and safety after a12-weeks treatment with atomoxetine hydrochloride (ATX) to the children with attention deficit hyperactivity disorder (ADHD).Methods:For a total of110cases of children with ADHD, who were treated with oral ATX for12weeks, estimate the efficacy by using Swanson child behavior scale IV (Swanson, Nolan and Pelham IV, SNAP-IV) on week0,4th,8th, and12th, and by using Conners Parents Questionnaire for the weeks of0and12th; and assess the safety by using Treatment Emergent Symptom Scale (TESS).Results:The scores of the SNAP-IV for the weeks4th,8th and12th were significantly lower than baseline, and the difference was statistically significant(P<0.01). The scores of Conners Parents Questionnaire for the week12th was lower than baseline and statistically significant(P<0.01), at all6observing factors, including morality problem, study problem, psychosomatic disorder, impulse-hyperactivity, anxiety and hyperactive index. The most common side effect was the gastrointestinal symptoms with an incidence rate of about30%, mainly appeared with anorexia or apocleisis; the secondly commen side effect was neurological symptoms with an incidence rate was4.5%. But all these side effects were mild or doubtable.Conclusions:This study shows it’s effective for the ADHD children to be treated with ATX, although ATX works slowly, it’s also safe, and no serious adverse event occurred. However, the drug adverse reaction should be taken care in time to improve the compliance.