Myelodysplastic Syndrome Cytogenetic Study On Clinical Application Of

Objective:To explore the implication of karyotype analysis in diagnosis and prognosis of myelodysplastic syndrome (MDS). Methods:The chromosomes were prepared with direct method, brief culture of cells and R-banding techniques, and then the karyotypic analysis w as performed. Reclassify the114patients with MDS according to the new Vienna classification and carry out analysis on their karyotype and cytomorphology. Results:forty-nine out of114patients (42.89%) had karyotypic abnormalities, including the numeral abnormalities of chromosomes and structural alterations.The most common chromosomal aberrations were+8.The rate of abnormal karyotype in RAEB1、2were much higher than others MDS.Patients with abnormal karyotype or higher IPSS scores had a higher risk of transformation into acute leukemia than patients with normal karyotype or lower IPSS scores (P<0.05). Conclusion:MDS is a highly heterogenous disorder and karyotype analysis is helpful for its diagnosis and prognosis estimation.