| Objective: Through retrospective analysis of the clinical data of patients with myelodysplastic syndromes(myelodysplastic syndromes,MDS)in the People’s Hospital of Jilin Province,explore the relationship between the age,blood cell analysis,chromosome karyotype,gene mutation and different diagnostic subtypes and prognostic stratification of MDS patients RelationshipMethods: Collect clinical data of patients with myelodysplastic syndrome diagnosed and treated in Jilin Province People ’ s Hospital from January 2015 to December 2020,and retrospectively analyze their gender,age,clinical manifestations,diagnostic subtypes,prognostic stratification,blood routine,lymphocyte subsets,bone marrow morphology The data of medical examination,bone marrow biopsy,flow cytometry,chromosome,gene mutation and other data were analyzed using SPSS22.0statistical software,and P<0.05 was statistically significant.Results:1、A total of 88 patients with MDS were included in this study,of which 55 were males and 33 were females.The male to female ratio: 1.66:1.2.Among 88 patients with MDS,the clinical manifestations were anemia as the first symptom,accounting for 89.77%,and most of them were moderate to severe anemia.Among the diagnosis subtypes,the patients with MDS-MLD subtype are the most,and the patients with MDS-U subtype are the least.In the prognosis assessment,the IPSS prognosis scoring system has 42 patients in the risk-1 group with the most patients,and the high-risk group with the least 3 patients;the IPSS-R prognostic scoring system: the extremely high-risk group has the most 21 patients,and the extremely low-risk group has the least 1 patient.3.The average age of 88 patients with MDS in this study was 65.88 years old,and the peak age of onset was 61-70 years old.Among the diagnostic subtypes,patients in the MDS-EB-2 subtype group are younger than those in the other subtype groups.In the IPSS prognosis scoring system,patients in the high-risk group are significantly younger than the other risk groups,which is statistically significant.4.Analysis of the blood routine of 88 patients with MDS,the results showed that the blood picture was mainly reduced in two-line and three-line.The platelet counts of MDS-EB-2 patients in each diagnostic subtype were lower.In the IPSS-R prognosis scoring system,the platelet count of patients in the very high-risk group was significantly lower than that in the other risk groups,which was statistically significant.5.Analysis of the karyotype of bone marrow chromosomes in 88 patients with MDS showed that the incidence of chromosomal abnormalities was 43.84%.Among the diagnostic subtypes,chromosomal abnormalities in MDS-MLD patients accounted for37.5% of the highest.In the IPSS prognosis scoring system,50% of chromosomal abnormalities in intermediate-risk-1 patients accounted for the most,and chromosomal abnormalities in low-risk patients accounted for the least 3.125%.6.39 cases of 88 MDS patients underwent genetic mutation testing.The results showed that the gene mutation rate was 84.6%.The mutation rate of splicing factor(42.42%)and epigenetic factor(39.4%)in the mutated gene was higher.Among them,ASXL1,U2AF1,SF3B1 is a gene with a high mutation frequency,and mutations in the SF3B1 gene are mainly found in MDS-RS subtypes.Among the diagnostic subtypes,the gene mutations of MDS-MLD patients accounted for the highest rate of 30.3%.In the IPSS prognosis scoring system,39.39% of patients with intermediate-risk-1 gene mutations accounted for the highest.Conclusion:1.MDS is more common in the elderly,with anemia as its main clinical manifestation.2.The reduction of blood cells,especially thrombocytopenia,is of great significance to the diagnosis and prognosis of MDS.3.Detection of chromosome karyotype and gene mutation is an important method for diagnosis and prognosis evaluation of MDS. |
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