Clinical Effect Of Postoperative Chemoradiotherapy And Prognostic Factors In119Patients With WHO Grade â…¢/â…£ Malignant Glioma

Objective: To evaluate the prognostic factors in patients with grade Ⅲ/Ⅳmalignantglioma and the clinical effect of postoperative chemoradiotherapy. Methods: The medicalrecords of119patients with malignant glioma were reviewed.49patients receivedpostoperative radiotherapy alone,21patients received postoperative radiotherapy plussequential nitrosoureas chemotherapy,49patients received postoperative radiotherapyplus concurrent and sequential temozolomide chemotherapy. The overall survival wascalculated by using Kaplan-Meier method, Log-rank method was used for univariateanalyses.Cox regression model was used for multivariate analyses. Results: Ultimately,the83patients with tumor recurrence. The median time to relapse was5.8months(0.6~45.5months), and the overall median survival time was13.3months(1.6~53.2months). The overall one-year survival rate was68%. The age, epilepsy, resection extent,concurrent chemoradiotherapy were the main prognostic factors affecting tumorrecurrence and survival related time (P<0.05).Moreover only the tumor pathologicalgrade was independent prognostic factors affecting the survival time(P<0.05).The tumortotal removal, radiotherapy concurrent and sequential temozolomide could improve thepatients’ one-year survival rate (P<0.05). Conclusion: To grade Ⅲ/Ⅳ malignant gliomapatients, the postoperative radiotherapy plus concurrent and sequential temozolomidechemotherapy can obtain good curative effect, but postoperative radiotherapy plussequential nitrosoureas chemotherapy can’t improve the prognosis of patients. The age <60years old、no seizures before the surgey、 tumor total resection、pathologic with gradeⅢ are beneficial to improve long-term survival.