The Study Of Correlation Of Serum Levels Of Neurotransmitter With Immune Levels On Post Traumatic Stress Disorder Patients

Objective：To explore the correlation between the change of immunocompetence and monoamineneurotransmitter level on post-traumatic stress disorder patients.Methods:1.Objective:The PTSD group was consist of35participants who experienced trauma,without physicalinjury and met the standard of Diagnostic and Statistical of Mental Disorders (DSM—IV).The controlgroup was consist of37participants who experienced trauma. Participants were trauma survivors orfamily member which were recruited from the first affiliated hospital of Shihezi university(Psychological rehabilitation division, Emergency surgery, Neurosurgery, Department of burn,Orthopaedics), between January2011to July2012.2.sampling: All the participants who experienced trauma were enrolled into the present study, includingpatients which met the diagnosis of PTSD and individuals which didn’t.3.Evaluation: we evaluated both demographic date a month later after the trauma happened and PCL-Cscale whthin two days that participants were enrolled into the group. If the score is more than41, theparticipant will be assessed by two psychiatric clinicians together.4.Materials:The plasma monoamine neurotransmitter （noradrenaline,5-hydroxytryptamine anddopamine）and the serum cell factor (Interleukin IL-2, IL-6, IL-10, tumor necrosis factor TNF–a) ofall the participants were detected with AEC-ELISA by use of Enzyme-linked immunosorbent which wasprovided by the biological technology of west don of Shanghai.5. Statistical methods:Use two independent samples nonparametric rank analyzed the datethat do not conform to the normal distribution. Correlation analysis including Pearson correlationanalysis was used when the date conform to the normal distribution and spearman correlation analysiswas used when the date do not conform to the normal distribution.(two-sided significance level0.05)Results：1.There was no significant difference about the plasma monoamine neurotransmitter（noradrenaline，5-hydroxytryptamine and dopamine）between the two group((p>0.05).2.There was no significant difference about The serum cell factor（Interleukin IL-2, IL-6, IL-10,tumor necrosis factor TNF–a）between the two group((p>0.05).3.There was no significant correlation between the plasma monoamine neurotransmitters（noradrenaline,5-hydroxytryptamine and dopamine) levels and the severity of PTSD（p>0.05).4.There was no significant correlation between the serum cell factors（Interleukin IL-2, IL-6, IL-10,tumor necrosis factor TNF–a）levels and the severity of PTSD（p>0.05)Conclusions：Single amine neurotransmitter and the immune function of PTSD patients are in a dynamicchange because of the interaction of the internal and external environments and the physical andchemical factors, it is significant to focus on Clinical manifestations, the rational use of drugs and disease treatment. In the present study, neither plasma monoamine neurotransmitter nor serum cell factorcomes to a positive result. The biological indicators above described need to be further researched aboutthe pathogenesis and the prevention of PTSD.