| Objective: Test for the clinical curative effects of Angong Niuhuang Bolus in treatingthe phlegm-heat syndrome of acute stage of ischemic apoplexy，depending on thedoctors’ and the patients’ evaluating indicators. Study preliminarily the relativitybetween the evaluation of the doctor’s diagnosis and treatment and that of thepatient’s self symptom. And probe into the superiority of the clinical curative effectsof Angong Niuhuang Bolus.Methods: The cases, which were the patients with the phlegm-heat syndrome of acutestage of ischemic apoplexy, brought into line according to the standard wererandomly divided into the treatment group and the control group with each group of30cases in the proportion of1:1. And both groups were given western medicineroutine treatment, treating14days. while the treatment group was additionally givenAngong Niuhuang Bolus,1bolus,2times a day, per oral or nasal feeding5days. Thetwo groups were observed14days. Criteria for Diagnose and Evaluation of CurativeEffect of Stroke, Standards of Syndrome-differentiated Diagnosis of Apoplexy, andStroke Patient Reported Outcomes(PRO) were measured and compared separately onthe1st,7th, and14thday, in order to evaluate the curative effects from the doctors andthe patients.Results:1. Clinical curative effect evaluation: the total effective rate of the treatmentgroup was93.4%, while the control group was86.7%. It was showed that there was asignificant difference (P<0.05) between the two groups, indicating that the curativeeffect of the treatment group was obviously superior to that of the control group.2.The scores of each group, which were measured from Criteria for Diagnose andEvaluation of Curative Effect of Stroke, the phlegm-heat syndrome belonging toStandards of Syndrome-differentiated Diagnosis of Apoplexy, and Stroke Patient Reported Outcomes(PRO), reduced notably (P<0.05,or P<0.01) on the7th,14thdaycompared with the1stday. There was a remarkable difference (P<0.05,or P<0.01)between the two groups according to the statistics process ed by that three scalesmentioned before. It was indicated that each group was effective in the improvementof the clinical curative effects of ischemic apoplexy, phlegm-heat syndrome and thesubjective symptom of patients, but the treatment group was superior to the controlgroup. Besides, through the comparisons on time intervals between the two groups,the treatment group was superior to the control group on the intervals of the1stto7thday, and the1stto14thday (P<0.05,or P<0.01), while the treatment group was equalto the control group on the interval of the7thto14thday (P>0.05).3.The incidencerate of six types of syndrome, according to Standards of Syndrome-differentiatedDiagnosis of Apoplexy, had decreased gradually or disappeared in the two groups by14days. The phlegm-heat syndrome still existed in2/3of the sufferers of the controlgroup, while in less than1/2of the treatment group, after14days’ treatment.4. Onthe7thday, the integral had positive correlation between the phlegm syndrome andthe heat syndrome; besides, the improvement of phlegm-heat syndrome wasrelationed with the reducing of the scores of PRO (r=0.499, P<0.01).Conclusions: The treatment group using Angong Niuhuang Bolus was superior to thecontrol group on the clinical curative effect，the speed of recovery, and the scoresreducing of Criteria for Diagnose and Evaluation of Curative Effect of Stroke, thephlegm-heat syndrome belonging to Standards of Syndrome-differentiated Diagnosisof Apoplexy, and PRO, in treating the phlegm-heat syndrome of acute stage ofischemic apoplexy. During7days of treatment, the phlegm syndrome was returningto normal following the recovering of the heat syndrome. The improvement ofphlegm-heat syndrome was relationed with the scores reducing of PRO, whichindicated that the improvement of syndrome was relative to the improvement ofsymptom. The research showed the advantage of Angong Niuhuang Bolus inameliorating the patients’s physiology, psychology, and social relations. |
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