Expression And Significance Of OPN And NF-ΚB In Henoch-schonlein Purpura

Purpose: Henoch-Schonlein purpura (HSP) is a systemic disorder characterized bythe deposition of immunoglobulin A (IgA)-containing immune complexesand complement components within small vessel walls. The pathogenesisand etiology is unknown，but the pathogenesis of HSP is related to immuneabnormalities. However, the OPN and NF-κB is involved in the immune.Therefore, By observing the changes in the serum, we studied whether theyplay a role in the pathogenesis of allergic purpura (HSP).Methods: Collect36cases whole blood who confirmed henoch-schonlein purpura(HSP) patients in our hospital dermatology from12-2012to04-2012of theexperimental group. Collected40cases whole blood of normal controlgroup.We used ELISA techniques to examine the levels of the OPN andNF-KB in Serum.Results: The expression levels of OPN in the serum of henoch-schonlein purpura(HSP) patients （(100.46±21.9）×102pg/ml）was significantly higher than thenormal control group（43.32±29.9）×102pg/ml）；The expression levels ofNF-κB in the peripheral blood of henoch-schonlein purpura (HSP) patients（44.66±10.52umol/L） was also significantly higher than the normalcontrol group（18.3±8.9umol/L）；there were Statistically significant, P <0.05,and both showed a linear correlation, r=0.59.The expression levels of OPNin the serum of henoch-schonlein purpura (HSP) nephritis patients((107.97±16.01）×102pg/ml）significantly higher than those without kidneydamage in patients with henoch-schonlein purpura (HSP)（（74.2±19.85）×102pg/ml）. The expression levels of NF-κB in the peripheral blood ofhenoch-schonlein purpura (HSP) nephritis patients（47.21±10.39umol/L） was also significantly higher than those without kidney damage in patientswith henoch-schonlein purpura (HSP)（35.71±4.42umol/L）；there wereStatistically significant, P <0.05, and both showed a linear correlation. OPNand24-hour urinary protein excretion was significantly positively correlated(P <0.05), there were statistically significant (r=0.402). NF-κB and24-hour urinary protein excretion was significantly positive correlation, r=0.18, P>0.05, no statistical significance.Conclusions:1. Expression levels of OPN and the NF-κB in the acute phase serum ofpatients with henoch-schonlein purpura (HSP) was significantly higher thanthe normal control group.2. OPN and NF-kappa B in the serum of patients with henoch-schonleinpurpura (HSP) were positively correlated.3. The expression levels of OPN and the NF-κ B in the serum ofhenoch-schonlein purpura (HSP) nephritis patients significantly higher thanthose without kidney damage in patients with henoch-schonlein purpura(HSP). OPN and24-hour urinary protein excretion was significantlypositively correlated (P <0.05), there were statistically significant (r=0.402).NF-κB and24-hour urinary protein excretion was significantly positivecorrelation, r=0.18, P>0.05, no statistical significance.