The Effect Of Occupational Exposure To Coke Oven Emission And Bezo [a] Pyrene On Blood Pressure And Electrocardiogram In Coke Oven Workers

Objective: The purpose of the study was to determine the levels ofB[a]P and COEs exposure in coke oven bottom, side and top of a cokeoven plant. The blood pressure and ECG was detected in all subjects. Wecombined the two experiments to explore the morbidity rate ofhypertension and abnormal ECG in coke oven workers, as well as the riskfactors leading to the disease, which is of great benefit to providing ascientific basis for preventing occupationally cardiovascular disease.Methods: The coke oven plant was selected as the exposure group andthe oxygen plant was selected as the control group. Parallel air samples incoke oven bottom, coke oven side, coke oven top and control group werecollected by air sampling pumps at the height of the personal breathingzone. The concentrations of B[a]P and COEs was detected by weighing andhigh performance liquid chromatography (HPLC).880Coke oven workersand710oxygen factory workers whose blood pressure, ECG and otheritems was detected were participated in this study. According to the data of occupational physical examination in the plants, the age, working years andoccupational history of all the subjects were collected.Results: There were no differences of sex, age and working years intwo groups (P>0.05). The concentrations of B[a]P and COEs in all cokeoven locations were significantly higher than in control group’s workplace(P <0.05). Among the coke oven locations, the concentrations were higherat the top and side than the bottom (P <0.05). The B[a]P levels at the topand side locations significantly exceeded the limit value. The COEs level atthe top locations significantly exceeded the limit value. The morbidity rateof hypertension and abnormal ECG in coke oven workers weresignificantly higher than controls (P <0.05). The detection ratio of grade Ihypertension and left ventricular high-voltage in coke oven workers weresignificantly higher than controls (P <0.05). By a logistic regressionanalysis, there were significant correlations between B[a]P low-exposure,B[a]P high-exposure as well as age and hypertension (P <0.05). The B[a]Phigh-exposure and age were the risk factors to abnormal ECG in coke ovenworkers (P <0.05). Moreover, B[a]P low-exposure, B[a]P high-exposure,sex and age were the risk factors of abnormal fasting plasma glucose incoke oven workers (P <0.05). Conclusion: B[a]P and COEs exposure in coke oven workers are therisk factors, which causes hypertension and abnormal ECG.