The Correlation Between HS-CRPMMP-9and The Degree Of Coronary Atherosclerosis In Traditional Chinese Medicine Characteristic Of Unstable Angina

Objective:1. To observe the distribution characteristics of syndrome elements of unstable angina pectoris in patients.2.To analysis of the distribution syndrome element of unstable angina pectoris In patients with coronary atherosclerosis development.3.To analysis of the relationship of HS-CRP、MMP-9in unstable angina pectoris patients with different level of coronary atherosclerosis.Methods:1. Reference to the diagnostic criteria for unstable angina, coronary angiography expressly incorporated by unstable angina patients given162cases, reference Gensini coronary artery score will be unstable angina were divided into A group, B group, C group.45cases of A group, B group of41cases,76cases in C group, TCM "syndrome" assessment by professional attending doctor of traditional Chinese medicine guide.2.Determination of inflammatory markers HS-CRP,MMP-9,calculation ofCoronary Atherosclerotic stenosis degree.3.All data were applied for statistical analysis by SPSS16.0package. count data, case number, count data, compared with the2test. Measurement data using mean±variance), two groups using t test, count data with non-normal distribution of nonparametric test Wilcoxon rank sum test.(P<0.05considered statistically significant difference).Results:1.The distribution of syndrome elements of TCM patients with unstable angina pectoris the total frequency of syndrome elements of TCM in162cases unstable angina pectoris are274in which blood stasis103cases (37.6%); phlegm68(24.8%),, deficiency of Qi56(20.5%); deficiency of Yin23(8.4%), Qi stagnation17(6.2%), damp-heat5(1.8%), deficiency of Yang in2(0.7%). TCM syndrome elements appears as follows:blood stasis, phlegm, Qi deficiency, qi stagnation damp-heat.deficiency of yang. That the pathogenesis of unstable angina pectoris is deficiency in origin and excess in superficiality, deficiency of Qi, blood stasis, phlegm and superficiality in, qi stagnation, documents in the frequency from high to low:Blood Stasis phlegm qi stagnation syndrome, and clip with phlegm and blood stasis card30(32.7%), deficiency of Qi and blood stasis in21(30.2%), a higher proportion of all.2.The distribution of syndrome elements of TCM unstable angina pectoris in patients with coronary atherosclerosis development:A group of TCM syndrome elements frequency percentage were:blood stasis23(30.8%), Qi deficiencyl7(22.7%), turbid phlegm13(17.3%), yin deficiency10(13.3%), qi stagnation10(13.3%), heat1times (1.3%),yang1(1.3%). B group of TCM syndrome elements frequency percentage were blood stasis25(35.2%):, phlegm20times (28.2%), deficiency of Qi17(23.9%), Yin5times (7.1%), and damp-heat3(4.2%),1(1.4%). C group of TCM syndrome elements frequency percentage were blood stasis55(43%):, phlegm35times (27.3%), deficiency of Qi22(17.2%), and Yin8times (6.3%), and heat4(3.1%),3(2.3%) Yang deficiency (0.8%).The distribution of syndrome elements of TCM has a significant difference among the three groups.3. With the development of coronary atherosclerosis increased gradually, HS-CRP, MMP-9level increased gradually, and in group C, HS-CRP, MMP-9levels were significantly higher than that of the other two groups, and has statistical significance (P<0.05). The CRP level of B group was higher than that of A group, and have statistical significance (P<0.05).4.In the document element, the level of HS-CRP from high to low is:Qi stagnation> blood stasis> phlegm=Qi; the level of MMP-9from high to low is:Qi deficiency> blood stasis>phlegm> Qi stagnation. Phlegm syndrome element of HS-CRP significantly higher than other syndrome elements of dawn, and there was statistical significance (P<0.05); the level of MMP-9had no statistical significance between the documents.5. TCM syndrome elements and folders Blockage common in phlegm, blood stasis, other evidence and folders prime too few cases, it is not included in the statistics. In the HS-CRP levels phlegm Blockage> blood stasis, but not statistically significant (P>0.05); at the level of MMP-9, traditional Chinese medicine and syndrome elements from high to low:blockage of phlegm and blood stasis, Qi deficiency and blood stasis, each accompanied syndromes there were significant differences.6.Document element groups to blood stasis in HS-CRP and MMP-9level was higher than that of no blood stasis, but without statistical significance (P>0.05), Document element groups to phlegm syndrome in HS-CRP and MMP-9level was higher than that of no phlegm syndrome, but without statistical significance (P>0.05), documents-qi deficiency in HS-CRP and MMP-9level lower than that of no qi deficiency, but without statistical significance (P>0.05). Stagnation of Qi in the HS-CRP and MMP-9levels lower than the no stagnation of Qi, stagnation of Qi and stagnation of Qi is a significant difference between the level of HS-CRP (P<0.05).Conclusion:1. Unstable angina to virtual sex hormone deficiency evidence-based, solid evidence known for blood stasis, phlegm, qi stagnation based,Unstable angina pectoris of coronary atherosclerosis in different degrees of TCM syndrome distribution has significant difference (P<0.05), which is mainly manifested as blood stasis was gradually increased, blood stasis may play an important role in the development of coronary atherosclerosis, blood stasis can be used as a predictive factor for unstable angina pectoris of coronary atherosclerosis.2.Phlegm syndrome in CRP expression was significantly higher than that of non-phlegm syndrome elements, and there is significant difference (P<0.05), phlegm syndrome elements can be used as unstable inflammation in patients with angina pectoris of a reference indicator of strong. Stagnation of Qi in the expression of CRP was significantly lower than that of non-phlegm syndrome elements, and there is significant difference (P<0.05) stagnation of Qi can be used as a reference index for inflammation in unstable angina pectoris patients response to weak.3. With the increase of unstable angina pectoris coronary atherosclerosis, HS-CRP, MMP-9levels increased, suggesting that HS-CRP, MMP-9plays an important role in the development of coronary atherosclerosis.