Correlation Between Lipid Levels And Cerebral Microbleeds In Patients With Acute Cerebral Infraction

Objective：To detect cerebral microbleeds (CMBs) in a cohort of acute ischemic strokepatients by susceptibility-weighted imaging(SWI). And To investigate whether there isa correlation between serum lipid levels and cerebral microbleeds.Methods：This is a cross-sectional study of104participants. Presence and number ofCMBs in consecutive acute ischaemic stroke patients admitted to our hospital fromJanuary2012to December2012were rated prospectively. All patients were examinedusing SWI and conventional Spin Echo(SE) sequence by siemens1.5T MR machine.Patients were divided into two groups according to the presence of CMBs in SWI.Mutivariate model were generated to determine the contribution of demographic、clinical and biochemical variables to the presence of CMBs. All of our findings werechecked and approved by attending physicians using the Brain Observer MicroBleedScale Stroke(BOMBS)to improve interrater agreement about CMBs. Satistical analysiswas performed with the Statistical Package of Social Sceences(SPSS,inc).Results：Of104patients,48(46.2%) had CMBs evident on SWI. In univariate analysiswith presence of CMBs as the outcomer, total cholesterol, triglycerides weresignificantly associated with the presence of CMBs (P=0.002,0.030,respectively).Inmultivariate logistic regression analysis, total cholesterol was an independent factorincreasing the risk of CMBs（P=0.029）.Conclusion：CMBs are more frequently noted in acute ischaemic stroke patients,aswell as those with low total cholesterol.