| Purpose: To investigate the application value of low dose whole pancreasperfusion imaging by using320slice dynamic volume CT, analyze the perfusiondifferences of pancreatic diseases and the microcirculation changes of early pancreaticcarcinoma,to provide a basis for early diagnosis and differential diagnosis of pancreaticcancer.Materials and Methods:21patients with clinically suspected pancreatic diseaseand9volunteers (26male,4female,24to73years old, the mean age50years)wereunderwent low dose whole pancreas CT perfusion imaged with Toshiba320-slice CTunit. Contrast agent Ultravist30ml-40ml (6-8ml/s,370mgiodine/ml) were intravenousinjected from right cubital vein following30ml saline at the same speed through thedouble cylinder high-pressure syringe with CT volumetric data acquisitionsynchronization. Perfusion data were calculated with maximum slope technique,timedensity curves,pseudo-color perfusion maps and arterial flow were generated. SPSS13.0for statistical analysis.Result: The perfusion study were successful in all cases,11cases were pancreaticcarcinomas,6acute pancreatitis with pancreatic head necrosis in1case,3chronicpancreatitis with false cyst formation in1case,9normal pancreases. Blood Flow ofnormal pancreatic tissue was117.0±12.05ml/min/100ml, pancreatitis was118.67±37.18ml/min/100ml, pancreatic cancer was67.16±18.94ml/min/100ml(F=8.59,p=0.0004). Pancreatic cancer group had a significant difference to normal pancreas andpancreatitis group (p<0.05), and perfusion maps can clearly show the differencebetween them, there is no significant difference between normal pancreas andpancreatitis group(p>0.05).The radiation dose were21.5to23.9mSv.Conclusion:At the basis of adequately preparation and respiratory training for the patients, reasonable application of contrast agent concentration, dosage and bolusinjection time, properly using scanning parameters and post processing software. Thistechnique can be a useful tool to evaluate hemodynamic change of pancreatic diseases,and have potential value in early diagnosis and differential diagnosis of pancreaticcancer. |
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