Diagnostic Significance And Prognosis Evaluation Of Polyplastocytosis In Epithelial Ovarian Cancer

Purpose:To discuss the clinical significance of CA125and serum blood plate increasementon benign and malignant ovarian tumor and their meaning to illness judegement andprognosis evaluation of epithelial ovarian cancer.Method:Have retrospective analysis and statistical analysis on clinical data and pathologyresults of50patients of benign ovarian tumor and17patients of epithelial ovariancancer.Results:(1)97cases are collected, include50cases of benign ovarian tumor with mean ageof55,47cases of epithelial ovarian cancer with.mean age of51. The illness age ofthem has no statistical significance.(2) The diagnostic rate of differential diagnosis of patients with benign ovariantumor and pithelial ovarian cancer by independent application of blood CA125andserum platelet are40.1%and43.3%respectively. The diagnostic rate of combinedapplication is68.3%. The positive correlation property exists in two methods.(3) There are15cases of patients at the early stage (stage I and II) of epithelialovarian cancer,5of them have thrombocytosis, the increase rate of platelet is33%.There are32cases of patients at the later stage (stage III and IV),18of them havethrombocytosis, the increase rate of platelet is56%. besides, the count of platelet ofpatients of pithelial ovarian cancer is apparently at the later stage higher than that ofpatient at the early stage. Both have statistical significance.(4) In33cases of middle-low differentiated epithelial ovarian cancer,20patients(accounting for60%) have serum platelet increasement,3patients (accounting for21%)of high differentiated epithelial ovarian cancer have serum platelet increasement.Besides, the count of platelet of patients of middle-low differentiated epithelial ovarian cancer is apparently higher than that of patients of high differentiated epithelialovarian cancer. Both have statistical significance.(5) In32cases of epithelial ovarian cancer at the later stage,18of them have serumplatelet increasement,14(14/18) of them have residual cancer focus after surgery≥2cm,14of them have normal platelet, wherein,4(4/14) of them have residual cancer focusafter surgery≥2cm. Both have statistical significance.Conclusion:The epithelial ovarian cancer usually appears dormant with no apparent clinicalmanifestation. It is usually at the later stage when it is found. Blood CA125is usuallyadopted for early diagnosis of epithelial ovarian cancer. Now it could be used incombination with serum and platelet. the research result shows that two items arepositively related. it could greatly improve the diagnosis of epithelial ovarian cancer andbenign ovarian tumor. What’s more, the later the stage of epithelial ovarian cancer is,the lower the differentiation, and the higher the count of two items, which indicate thesetwo items are closely related to the illness of the tumor. In the mean time, the proportionof patients of epithelial ovarian cancer with platelet higher than the normal with residualcancer focus≥2cm is large. Poor prognosis is suggested.