Study On The Correlation Between Blood Pressure Ratio And The Target Organ Damage In Patients With Primary Hypertension

Objective: the study by monitoring24hours ambulatory blood pressure in elderprimary hypertension patients, to investigate the relation between nSBP/dSBP and thetarget organ damage of primary hypertension patients;Methods: There are total200patients with primary hypertension in the fourthpeople’s hospital of ShenYang between January1,2012and September30,2012attending this study. We obtained informed written consent from patients afterexplaining the procedure and risk. Patients have primary Hypertension duration≥5years. between50and75years of age were eligiable for inclusion into this study if thelong-term use of multiple antihypertensive drugs, including: β-blockers, angiotensinconverting enzyme inhibitors (ACEI), angiotensin II receptor antagonist (ARB), along-acting calcium antagonist (CCB) and diuretics.The following exclusion criteriaswere required for patient enrollment: secondary hypertension, symptoms of high bloodpressure, congenital heart disease, valvular heart disease, hyperthyroidism, atrialfibrillation, diabetes, blood lipid abnormality (LDL-C>3.1mmol/L, TG>1.7mmol/L),smokers. They need to stop taking antihypertensive drugs7-10days before monitoring24hours ambulatory blood pressure. To record their daytime blood pressure andnighttime blood pressure, calculate nSBP/dSBP, and according to the ratio of differentwere divided into A group, a total of36people (nSBP/dSBP<0.8); group B, a total of31people (nSBP/dSBP=0.8~0.9); group C, a total of52people (nSBP/dSBP=0.9~1);group D, a total of81people (nSBP/dSBP>1).SPSS software was used for statisticalanalysis between different groups, the severity of target organ damage.Results:1, Comparison of four groups of patients with general information: four groups ingender, age, hypertension duration,24hours average systolic blood pressure showed no significant difference(P>0.05).2, B group (nSBP/dSBP=0.8~0.9) and the other three groups: A group(nSBP/dSBP<0.8), C group (nSBP/dSBP=0.9~1), group D (nSBP/dSBP>1) werecompared, heart, brain, kidney and target organ damage rate is the lowest, there wassignificant difference (P<0.05).3, Group D (nSBP/dSBP>1) and the other three groups: A group(nSBP/dSBP<0.8), B group (nSBP/dSBP=0.8~0.9), C group (nSBP/dSBP=0.9~1)were compared, heart, brain, kidney and target organ damage rate, there was significantdifference (P<0.05).4, Group A (nSBP/dSBP<0.8) and C group (nSBP/dSBP=0.9~1), there was nosignificant difference (P>0.05).Conclusions:24hour ambulatory blood pressure monitoring can change in bloodpressure circadian rhythm changes of reaction, the effects on target organ damage inpatients with hypertension of different. Significant damage related circadian bloodpressure curve anomaly and target organ. And the night average systolic blood pressureand ambulatory systolic pressure ratio can be concise, judgment of circadian bloodpressure curve conveniently is abnormal, It can be used as the primary predictor ofhypertension with target organ damage and the evaluation method of.