Preliminary Study On The Correction Parameters And Advantages Of18F-FDG PET-CT In The Diagnosis Of Glioma Grading

Objective: To compare the value of¹⁸F-Fluorodeoxyglucose (¹⁸F-FDG)positronemission tomography combined with computed tomography （PET/CT） and MRI inpatients with brain glioma, and analyze their difference thus provide evidences foraccurate diagnosis of brain glioma grading. Using maximum correction method toobtain a more accurate PET-CT parameters critical value to glioma grading diagnosisand to provide a more comprehensive, accurate and reliable imaging information fordetermining treatment plans.Methods: Setting three groups include the PET-CT imaging group, MRI imaging groupand normal control group. PET-CT imaging group was composed of twenty patients andfive healthy volunteers, all of which doing intravenous injection of¹⁸F-FDG afterfasting for more than6hours, then to execute PET-CT scan of the head after resting indark, quiet condition for one hour. Iterative method of PET-CT imaging group usingordered subset expectation maximization for image reconstruction; image attenuationcorrection was performed with CT data. The reconstruction of CT image reconstructionusing standard methods. The PET and CT images were submitted to Xeleris workstationto display the fused frame-to-frame contraposition image. Forty patients and ten healthyvolunteers constitute MRI imaging group, and all of them to be examined by MRI scan,enhance and DWI. All MRI data after MRI workstation synthesis and integration.Pathologic diagnosis was obtained by biopsy or open surgery in all patients with tumor.PET-CT imaging were analyzed in visual and semi-quantitative approaches. TheSUVmax, SUVcorrectand L/WM were calculated. To compare the PET-CT and MRI imageanalysis results with the patient’s pathology and follow-up results, and calculateddiagnostic sensitivity, specificity and accuracy on brain glioma grading of PET/CT and MRI. To conducted one-way ANOVA of SUV, SUVcorrect and L/WM.Results:①The postoperative pathology test results confirmed that forty patients with afinal diagnosis of glioma in the sixty, and other types of highly malignant tumor in12cases,8cases of non-neoplastic lesions.②Compared PET-CT and MRI in the diagnosisof glioma grading, final diagnosis correlation between PET-CT was97.5%, and95%with MRI.③PET-CT diagnosis of glioma grading in sensitivity, specificity, accuracyresults are all higher than MRI, in which the class II, class III identification better than I,IV.④PET-CT SUV value, L/WM value,SUVcorrect value comparison between thedifferent glioma levels were statistically difference（p<0.05）, and SUVcorrect valuebetween grade II, III and gradeI, IV were significant difference （p<0.01）.Conclusion:①¹⁸F-FDG PET-CT is superior to MRI on diagnostic performance ofglioma.②¹⁸F-FDG PET-CT is more suitable for glioma grading than MRI, and theability to identify grade II, grade III gliomas is superior to grade I and IV level.③Theparameters SUVcorrect value of PET-CT compared with the SUV values is moresensitive for glioma grading identify.