The Case-control Study On Part Of The Risk Factors Associated With Hashimoto’s Thyroiditis(HT) With Thyroid Cancer

Objective: Through the case-control study on part of the risk factors associatedwith HT with thyroid cancer,preliminary investigate the relationship between HT andthyroid cancer and the possible factors that lead to the disease,in order to guide theclinical work.Methods:330cases of HT admitted to the general surgery of the Second AffiliatedHospital of Dalian Medical University from January2003to January2013wereretrospectively analyized,including32cases of male and298female,age14～83yearsold.The65cases of HT with thyroid cancer were analyzed as the case group,comparingwith the remaining265cases of HT with benign thyroid nodules or with HT alone.Thepatient’s age, gender, family history, iodine intake, history of radiation exposure, theautoantibodies performance, blood TSH levels, a merger of the solitary thyroid noduleswere introduced as factors to be stutied.The count date was analyzed by chi-square testor Fisher exact probabilities,as well as single factor conditional logistic regressionanalysis.The factors that were significantly different were filtered out and once againanalyzed by multivariate conditional logistic regression analysis.Finally, the risk factorsassociated with HT with thyroid cancer were ensured.Results:Through the single factor analysis of the eight factors above,the resultsshowed that age, gender, family history, iodine intake, history of radiation exposure andautoantibodies had the difference of statistics（P<0.05),which may lead to HT withthyroid cancer.Group comparisons of the iodine intake were applied,showing the resultthat it was significantly different between the high iodine intake and the normal iodineintake,which suggested that high iodine diet relative to other levels of iodine intake wasmore likely to cause the disease.The factor of autoantibodies was eliminated after thesix factors initialiy filtered were analyzed using multivariate conditional logisticregression analysis.As a result,age, gender, family history, iodine intake (high iodine intake), history of radiation exposure were determined as risk factors for HT withthyroid cancer.Conclusion:Age, gender, family history, high iodine intake, history of radiationexposure were risk factors for HT with thyroid cancer.The pathogenesis is the result of acombination of factors including cancer gene mutation, gene rearrangement, endocrinedisorders and autoimmune abnormalities.And moreover,it may be subject to otherrelevant factors.