Metabonomics Mechanism Study On Irritable Bowel Syndrome (IBS) Of Spleen Deficiency Type By Medicine-separated Umbilical Moxibustion

Objective:The study tries to investigate the metabolic level differences betweenmedicine-separated umbilical moxibustion and starch-separated umbilicalmoxibustion.Trying to find out potential biological markers and derive related metabolicpathway of umbilical moxibustion on irritable bowel syndrome of spleen deficiency.Inorder to determine the efficacy of umbilical moxibustion.Method:24irritable bowel syndrome of spleen deficiency patients were randomlydivided into two groups.Dealing with this group of patients urine and plasma samplesbefore and after treatment.According to the Simca-P11.5software package processing data,look for the contribution of the metabolite fractions and search of related metabolicpathway by HMDB、KEGG.Results:medicine-separated umbilical moxibustion and starch-separated umbilicalmoxibustion have undergone significant changes.Changes in more significant are aminoacids, catecholamines and bile acids, these metabolites involved in amino acid metabolismand neurotransmitter metabolism.Medicine-separated umbilical moxibustion also involvesendogenous cannabinoids metabolism.Starch-separated umbilical moxibustion alsoinvolves arachidonic acid metabolism.Conclusion:The umbilical moxibustion can significantly inhibit the irritable bowelpatients with visceral hypersensitivity,improve intestinal nervous immune,endocrine disorder state,alleviate clinical symptoms and improve the diarrhea type irritable bowelpatients’ life quality.From a metabolic point of view,the clinical efficacy of themedicine-separated umbilical moxibustion is superior to starch-separated umbilicalmoxibustion.