The Clinical Significance Of Serum Carcinoembryonic Antigen Detection In Rheumatic Diseases

Objective: Understanding through observation of patients withrheumatic diseases serum carcinoembryonic antigen levels ofcarcinoe-mbryonic antigen detection in rheumatic diseases.Methods： Inspection from January2010to March2013the SecondAffiliated Hospital of Dalian Medical University, Division ofRheum-atology confirm the diagnosis of rheumatic diseases simultaneouslyca-rcinoembryonic antigen detection and exclude tumor hospitalizedpatie-nts with clinical data. Analysis of the composition of the patientswi-th elevated serum carcinoembryonic antigen rheumatic diseases andc-omplications, disease activity. Analysis of serum carcinoembryonicant-igen levels and erythrocyte sedimentation rate, C-reactive protein,im-muneoglobulin correlation. Statistical Methods: SPSS17.0statisticalso-ftware for statistical analysis, results are expressed as mean standarddeviation, compared with paired samplet test, P<0.05as significantdifference.Results：1.Elevated serum CEA, rheumatic disease incidence anddistribut-eeion of diseases2018tested serum CEA and confirm the diagnosis of rheumaticdiseases in patients with neoplastic diseases, elevated serum CEA inpatients with36people (49people),accounting for1.78%, elevatedpre-treatment serum CEA lev-el5.12-12.82ng/ml,average (6.59±1.77) ng/ml.Cause elevated serum CEA dise-ases, including rheumatoid arthritis in21cases,3cases of systemic lupus eryt-hematosus, dermatomyositis,undifferentiated connective tissue disease, systemi-c lupus overlap syndrome (the RA overlap dermatomyositis, RA overlap)2For example,Wegener’s granulomatosis, adult-onset Still’s disease, recurrentpolychondritis, ankylosing spondylitis, reactive arthritis, gouty arthritis inlcas-e.2.serum CEA levels in patients with clinical features(1).36patients with target organ damage in elevated serum CEA jointsw-elling and pain28,22lung involvement, blood system involvement,renal inv-olvement each muscle damage, skin rashes, liver damage,vascular involveme-nt each.(2).36patients coinfected with elevated serum CEA coinfection(8people) are lung infections. Infection after treatment the serum CEAabnormal return to normal3(7people), serum CEA levels returned tonormal74-714days. Inf-ection before and after treatment serum CEA levelswere5.12-12.82ng/ml,(a-verage6.85±3.03ng/ml);1.52-3.3ng/ml (mean2.41±1.43ng/ml). Infection treatme-nt serum CEA levels were significantlylower than before treat-ment, infection treatment serum CEA comparison,P=0.044, P<0.05, significant difference. In-fection after treatment serumCEA levels did not return to no-rmal people (1p-erson), infection,pre-treatment serum CEA was5.91ng/ml after infection tre-atment serumCEA was6.62ng/ml, elevated serum CEA duration of306days.3.inflammation (inflammatory markers: erythrocyte sedimentation rate,cre-active protein, immunoglobulin)36patients with serum CEA patients with elevated serum CEAincreased active disease, its ESR, CRP abnormal number of cases were31,30, line18immunoglobulins, immunoglobulin abnormalities17. Aftertreatment increased serum CEA level review of serum CEA of22people(28people), line immuno-globulin detection14. Before and after treatmentCEA, ESR, CRP, immunoglo-bulin G levels were5.12-12.82ng/ml, average(6.70±2.21)ng/ml,1.52-12.12ng/ml, average (4.65±2.13) ng/ml;4-120mm/h,average (45.54±31.61)mm/h,5-120mm/h, average (34.29±34.63)mm/h;2.29-147ug/ml, average (31.56±36.07) ug/ml,2.92-46.2ug/ml, average(14.25±14.24) ug/ml;7.64-19g/L, average (12.40±4.22)g/L,6.28-22.92g/L,average (10.91±4.67)g/L significant difference (P<0.05) before and after treatment CEA, ESR, CRP, immunoglobulin G, the P value0.002,0.046,0.003. Immunoglobulin A, immunoglobulin M,immunoglobulin E le-vels before and after treatment were2.12-5.54g/L,average (3.38±1.05)g/L,1.88-6.04g/L, average(3.46±1.14)g/L;0.32-2.42g/L, average (1.27±0.58)g/L,0.48-2.69g/L,average (1.25±0.56)g/L;8-768IU/mL, average(165.70±240.83)IU/mL,6-624IU/mL, average (179.72±200.80)IU/mL, nosignificant difference (P>0.05) before and after treatment IgA, IgM, IgEbetween P values were0.656,0.879,0.81.Conclusions： Serum CEA levels found in a variety of rheumaticdiseases. Rheumatic diseases in patients with serum CEA levels more lungand joint in-volvement. Rheumatic diseases in patients with serum CEAlevels associated with inflammation in the body (infection and diseaseactivity).