Fiber Web Struction Of Multilayer Composite Chitosan Spunlace Efunctional Wound Dressing And Study Of Performance

In recent years, with the developed standardization of wound dressing, the users pay more attention on how to care for the damaged wound caused by abrasion, operative incision, diabetic ulcers and varicose ulcer, therefore, the wound dressing with hemostasisl, promoting healing wound and better biocompatibility is in urgent need in the market. Chitosan fiber has antibacterial, antiphlogistic, hemostasis and promoting healing wound effects, and it has the advantages in various wound dressings with hygroscopicity, air permeability and better biological compatility, so it is very suitable for bare and protective wound. However, chitosan fiber has some problems such as poor mechanical properties and less crimp, spinning pure chitosan fiber exist many difficulties, and the price of chitosan fiber is higher, the preparation of wound dressing with better performances and appropriate cost is of great realistic significance.Spunlace nonwoven products have a series of advantages, such as soft hand, Hygiene, air permeability, hygroscopicity and no hairiness, meanwhile, the products in the field of world health care have been widely applied. Therefore, this paper chooses the chitosan fiber, viscose fiber and polyester fiber as the materials to prepare functional wound dressing, focusing on the following four aspects:Firstly, the basic mechanical properties of the chitosan fiber, viscose fiber and polyester fiber were tested and analyzed, focusing on the surface morphology, deacetylated degree of chitosan fiber and the mechanical property of three kinds of fibers; Secondly, prepared seven kinds of multilayer composite chitosan spunlace functional wound dressings with different ratio of fiber and the orientation of fiber in the functional layer; Thirdly, analysed the rigid and flexible, hygroscopicity, diffusivity, air permeability, moisture penetrability, pH value, soluble substance from the material properties and different web structure. Finally, selected the representative samples and L-929fibroblast to co-culture, by observing the morphological changes and proliferation of cell to evaluate its cell compatibility, meanwhile, using absorptive method to evaluate its antibacterial performance.This paper obtained the following results from the above studies:(1)Chitosan fiber has better hygroscopicity, but less crimp, bigger initial modulus and rigidity.(2)The defect of chitosan fiber, prone to break in carding100%chitosan fiber, thus a second carding was needed, when the chitosan fiber and viscose fiber of functional layer mixed according to a certain proportion, the carding effects improve significantly, and with the increase of viscose fiber content, carding effects become better.(3)Seven different multilayer composite chitosan spunlace functional wound dressings possess better mechanical properties, such as softness, hygroscopicity, moisture-penetrability and air permeability, meanwhile, chemical performance indexs like the height of superficial foam and the amount of soluble substance all conform to medical industry standards, the liquid absorption rate and the air permeability rate is as high as1345%and850mm/s respectively, the height of superficial foam almost approach0, the amount of soluble substance<0.5%.(4)Seven different multilayer composite chitosan spunlace functional wound dressings possess better cell compatibility and better antibacterial effect, L-929fibroblasts can proliferate and differentiate on the surface and internal of samples, and cell morphology is normal, antibacterial rate above90%.