A Study On Correlations Between Imaging Appearances And Serum MMP-2、bFGF Expression In Primary Lung Carcinoma

Objective: To investigate the correlation between the expression of serum matrixmetalloproteinase2(MMP-2) and basic fibroblast growth factor (bFGF) in patients withprimary lung cancer and its CT and DSA imaging appearances.Method: Data of images（CT，DSA）and clinical were Collected on35patients withprimary lung cancer undergoing endovascular interventional treatment, who had beencomfirmed by pathological detection. The serum sample of patients was collectedbefore interventional therapy, the concentration of serum bFGF and MMP-2of35lungcancer patients and35normal controls was detected by enzyme-linked immuno-sorbentassays (ELISA), finally the relationship was evaluated between the expression level ofserum bFGF and MMP-2and the appearances of CT,DSA and clinical.Results:[1] The concentration of serum MMP-2(66.43±58.64ng/ml) and bFGF (40.85±22.12pg/ml) in patients with lung cancer were significantly higher than serumMMP-2(31.00±23.17ng/ml) and bFGF (15.60±13.59pg/ml) in the controls, P <0.01;[2] The positive correlation was found between serum MMP-2, bFGF in lungcancer group and that in normal control group, the correlation coefficient is0.5930and0.762respectively, P values were less than0.01;[3] DSA showed that rich blood-supplyexisted in7patients while the tumor with poor blood-supply existed in the14patients,middle blood–supply in14patients, the concentration of serum MMP-2is170.02±29.22ng/ml,19.97±15.11ng/ml,61.10±15.44ng/ml respectively, there were highly differences of the serum MMP-2concentration between different blood supply，P <0.01; the concentration of serum bFGF is72.38±15.25pg/ml,25.08±13.10pg/ml,40.85±14.06pg/ml respectively, there were highly differences of the serum bFGFconcentration between different blood supply,P <0.01;[4] The necrotic cavity,spiculation and deep lobulation of Lung cancer lesions on CT images were related to theexpression levels of serum MMP-2, bFGF. the concentration of serum MMP-2(104.26±70.80ng/ml) and bFGF (56.60±20.51pg/ml) in patients with necrosis tumor werehigher than MMP-2(51.29±46.45ng/ml) and bFGF (34.55±19.77pg/ml) in patientswithout necrosis, P <0.05); the concentration of serum MMP-2(114.67±67.53ng/ml)and bFGF(58.52±22.33pg/ml) in patients with spiculation were higher thanMMP-2(37.92±25.88ng/ml) and bFGF(30.41±14.13pg/ml) in patients withoutspiculation, P <0.01; the concentration of serum MMP-2(125.96±60.51ng/ml) andbFGF(56.67±23.44pg/ml) in patients with deep lobulation were higher thanMMP-2(35.37±23.30ng/ml) and bFGF(32.60±16.55pg/ml) in patients without deeplobulation, P <0.01. the size, location of lesion and blocking pneumonia were notrelated to the expression level of serum MMP-2, bFGF.[5] The clinical TNM stage oflung cancer was related to the expression level of serum MMP-2, bFGF. Theconcentration of serum MMP-2(101.81±60.11ng/ml) and bFGF (50.75±22.92pg/ml)in patients with clinical stage of ⅢB-IV were significantly higher than serum MMP-2(28.96±23.85ng/ml) and bFGF (30.37±15.96pg/ml) in the patients with clinicalstage of IB-ⅢA, P <0.01.the expression of serum MMP-2, bFGF in the patients withlung cancer has nothing to do with gender, age, Pathological types or Degree of celldifferentiation.Conclusion:[1] DSA appearance of lung cancer was related to the expression level ofserum bFGF, MMP-2in patients, both of them reflect to State of tumor angiogenesis,and can be used as a indications to interventional therapy and anti-angiogenesis therapy;[2]CT features about necrotic cavity, spiculation and deep lobulation of Lung cancer lesions were related to the expression levels of serum MMP-2, bFGF. CT findingsassociated with the expressionof serum MMP-2, bFGF help to accurately estimate thedegree of the severity of the disease;[3] The expression levels of serum bFGF andMMP-2were related to clinical stages. They reflected extent of tumor progress, as aindicator to select patients for interventional treatment, can evaluate prognosis ofpatients with lung cancer.