Relationships Between Lipid Levels And Sex In Patients Of Coronary Heart Disease

Objective: Dyslipidemia and cardiovascular disease are closely related itmay affect vascular function through multiple mechanisms, leading toatherosclerosis. Diabetic patients are often accompanied by dyslipidemia, thusincreasing the incidence and mortality of cardiovascular disease. Because theepidemiological data display that the morbidity and mortality ofcardiovascular disease in male patients are higher than that of female patients.Therefore, the situation of female patients have not attracted enough attention,and blood lipids are risk factors in cardiovascular disease. This study wasdesigned to study the relationship between blood lipid levels and gender incoronary heart disease and coronary heart disease with diabetes.Methods:300coronary heart disease and coronary heart disease withdiabetes in department of cardiology of the second hospital affiliated to HebeiMedical University were enrolled in this study. Patients met the inclusioncriteria, divided into groups of non-fat meal, fat meal group, overall CHDpatients were divided into Simple CHD group (group A), coronary heartdisease with diabetes group (group B), again divided into two groups of malepatients with simple coronary heart disease group (group A1),female patientswith simple coronary heart disease group (group A2), coronary heart diseasein male patients with diabetes group (group B1), coronary heart disease infemale patients with diabetes group (group B2),the fat meal group is dividedinto simple coronary heart disease fat meal group (group C), coronary heartdisease with diabetes fat meal group (group D), the two groups were againdivided into four groups of male patients with simple coronary heart diseasefat meal group (group C1), female patients with simple coronary heart diseasefat meal group (group C2), coronary heart disease with diabetes fat mealgroup of male patients group (group D1), coronary heart disease with diabetes fat meal group of female patients group (group D2),before the test, fat mealgroup take into low-fat diet, fasting10-12h later, in the early morning of thefirst test collected fasting blood5ml.Eating the test meal (meal within30minutes to complete), with reference to foreign standards and the Chinesepeople’s eating habits combined with improved customization. Calorie600kcal/m2body surface area, the energy of fat, protein and carbohydrateprovides60%,14%and26%. Fat meal by the standard quantitative sausage,fried dough sticks, milk composition. After a fatty meal nutrition professionalnutritionist according to the patient’s height, weight, body surface areacalculated quantitatively formulated. After the meal, respectively2h,4hvenous blood5ml, timely separation of serum,-70℃preservation. Avoidmovement during the test.Results：1General comparison between male group and female group.The two groups in age (Male:57.33±18.34Female:53.24±10.78P=0.876),body mass index (Male:26.46±1.87Female:27.19±1.98P=0.896), duration ofcoronary heart disease (Male:10.33±1.24Female:10.98±1.25P=0.567),duration of diabetes(Male:11.26±1.14Female:11.65±1.25P=0.579), fastingblood glucose(Male:7.58±1.56Female:6.24±1.36P=0.785) have nosignificant difference (P>0.05).2Comparison of different groups of patients about hyperlipidemia.2.1Simple CHD group211cases (group A) and coronary heart diseasewith diabetes group89cases (group B) comparing fasting lipidFasting TG(group B:3.30±0.05mmol/L),fasting CHOL (groupB:5.09±0.04mmol/L), fasting LDL-C (group B:2.93±0.04mmol/L)of patientsin coronary heart disease with diabetes group are significantly higher than thatof the patients in simple CHD group (group A:3.27±0.08mmol/L, groupA:5.07±0.07mmol/L, group A:2.86±0.04mmol/L,)(P<0.05),the difference hasstatistically significant. Fasting HDL-C (group B:0.97±0.02mmol/L) ofcoronary heart disease with diabetes group is significantly lower than that ofsimple CHD group (group A:0.98±0.01mmol/L)(P <0.05), the difference has statistically significant.2.2Male patients with simple coronary heart disease group110cases (groupA1) and female patients with simple coronary heart disease group101cases(group A2) comparing fasting lipidFasting TG(group A2:3.29±0.07mmol/L),fasting CHOL (groupA2:5.09±0.07mmol/L), fasting LDL-C(group A2:2.87±0.06mmol/L) ofpatients in female patients with simple coronary heart disease group are higherthan that of the male patients with simple coronary heart disease group(groupA1:3.25±0.07mmol/L,groupA1:5.05±0.04mmol/L,groupA1:2.82±0.06mmol/L)(P>0.05)，the difference has not statistically significant. Fasting HDL-C(groupA1:0.95±0.01mmol/L) of male patients with simple coronary heart diseasegroup is lower than that of simple CHD in female patients (group A2:1.02±0.02mmol/L)(P <0.05), the difference has statistically significant.2.3Coronary heart disease in male patients with diabetes group50cases(group B1) and coronary heart disease in female patients with diabetes group39cases (group B2) comparing fasting lipidFasting TG (group B1:3.35±0.13mmol/L), fasting CHOL (group B1:5.12±0.09mmol/L), fasting LDL-C(group B1:2.96±0.02mmol/L) of patients incoronary heart disease in male patients with diabetes group are significantlyhigher than that of the patients in coronary heart disease in female patientswith diabetes group (group B2:3.22±0.06mmol/L, groupB2:5.07±0.05mmol/L, group B2:2.91±0.09mmol/L)(P <0.05), the differencehas statistically significant. Fasting HDL-C(group B1:0.96±0.02mmol/Lgroup) of patients in coronary heart disease in male patients with diabetesgroup is lower than that of the patients in coronary heart disease in femalepatients with diabetes group (group B2:0.99±0.04mmol/L)(P<0.05), thedifference has statistically significant.2.4Male patients with simple coronary heart disease fat meal group44cases(group C1) and female patients with simple coronary heart disease fatmeal group40cases(group C2) comparing fasting lipidPostprandial2hTG (group C1:3.35±0.26mmol/L), postprandial4hTG (group C1:4.55±0.35mmol/L) of patients in male patients with simplecoronary heart disease fat meal group are higher than that of the femalepatients with simple coronary heart disease fat meal group(groupC2:2.67±0.24mmol/L, group C2:3.66±0.15mmol/L)(P>0.05),the differencehas no statistically significant.2.5Coronary heart disease with diabetes fat meal group of male patientsgroup20cases(group D1)and coronary heart disease with diabetes fat mealgroup of female patients group16cases(group D2)comparing fasting lipidPostprandial2hTG (group D1:4.03±0.13mmol/L), postprandial4hTG(group D1:4.05±0.13mmol/L) of patients in coronary heart disease withdiabetes fat meal group of male patients group are significantly higher thanthat of the patients in coronary heart disease with diabetes fat meal group offemale patients group(group D2:3.42±0.36mmol/L, groupD2:4.04±0.54mmol/L)(P<0.05), the difference has no statistically significant.Conclusion: Fasting TG, fasting CHOL fasting LDL-C of patients incoronary heart disease with diabetes is higher than that of patients in coronaryheart disease, HDL-C is lower than that of patients in coronary heart disease;Fasting TG, fasting CHOL fasting LDL-C in male patients with simplecoronary heart disease group have no statistical significance between male andfemale, male patients’ HDL-C is lower than that of female patients; FastingTG, fasting CHOL fasting LDL-C of male patients in coronary heart diseasewith diabetes are higher than that of female patients, HDL-C is lower than thatof female patients; Postprandial2hTG, postprandial4hTG is not statisticallysignificant between male and the female in simple coronary heart disease;Postprandial2hTG, postprandial4hTG of male patients in coronary heartdisease with diabetes are higher than that of female patients.