Associations Of Osteoporosis And Pulmonary Fibrosis In The Elderly People

Objective:To study the associations of osteoporosis and Pulmonary Fibrosis s in theelderly peopleMethods:104senile resident patients and outpatients of China-Japan Union Hospitalof Jilin University were selected for the study. And dual-energy X-rayabsorptiometry(DXA) was used to measure the bone mineral density(BMD) inthe area of lumbar spine and femur of the body. At the same time GElight-speed VCT was adopted to measure grid pattern changes of lung. Thendepend on the value of BMD and grid pattern changes of pulmonary fibrosis,participants were divided into osteoporosis group and non osteoporosis group,fiber reticular shadow group and non fiber reticular shadow group. In order tocarry on statistical analysis by the software packets SPSS17.0, recording andmeasurement general conditions, existing related risk factors, related serumbiochemical index, grid pattern changes of double lungs, pulmonary function,arterial oxygen pressure values(PO2) and bone mineral density values(BMD) ofparticipates were did.Results:1. The possibility of IPF patients who suffer union osteoporosis is higherthan that in non IPF patients. The possibility of osteoporosis patients whosuffer union IPF is higher than that in non osteoporosis patients.2. Age ofpatients in the elderly osteoporosis group is significantly higher than that in nonosteoporosis group. And differences have statistical significance(P＜0.05). Theproportion of female patients in osteoporosis group is significantly higher than that in non osteoporosis group. And differences have statistical significance(P＜0.05). BMI is in osteoporosis group is significantly lower than that in nonosteoporosis group. And differences have statistical significance(P＜0.05). Thelevel of serum ALP in osteoporosis group is higher than that in nonosteoporosis group. And differences have statistical significance(P＜0.05).Differences between two groups in the level of serum HbA1c, Ca, PO4, etc donot have statistical significance(P＞0.05).3. The level of serum VD total inosteoporosis group is significantly lower than that in the latter. While the levelof serum TNF-αis higher than the latter(P＜0.05). Based on Spearmananalysis, the level of VD total is positive correlated with bone density(P＜0.05),and the level of TNF-α is negative correlated with bone density(P＜0.05).4. The incidence rate of diabetes mellitus, smoking, pulmonary fibrosis,sexuality, restrictive ventilatory disorder, diffusion dysfunction and meionecticblood is significantly higher in osteoporosis group than that in non osteoporosisgroup. And differences have statistical significance(P＜0.05).5. Influencefactor of osteoporosis Logistic indicate：diabetes mellitus is major risk factor ofsenile osteoporsis, while BMI is a protective factor of osteoporosis.6. Age,BMD, and BMI of patients in fiber grid shadow group is lower than that in nonfiber grid shadow group. And differences have statistical significance(P＜0.05).The level of serum VD total is significantly lower in fiber grid shadow groupthan that in non fiber grid shadow group(P＜0.05). While the level of serumTNF-αis higher than the latter(P＜0.05).7. The incidence rate of diabetesmellitus, smoking, sexuality, osteoporosis in fiber grid shadow group issignificantly higher than that in non fiber grid shadow group. And differenceshave statistical significance(P＜0.05).8. Influence factor of pulmonary fibrosisLogistic indicate: age is major risk factor of pulmonary fibrosis. Whileosteoporosis which is another risk factor of pulmonary fibrosis have a certain influence for the incidence.Conclusion:Senile osteoporosis is a systemic disease whose mainly symptom is lowerbone mineral density. Pulmonary fibrosis is a diffuse interstitial pulmonarydisease, but the reason for which is undefined. Clinically the most commonsymptom of pulmonary fibrosis is progressive reduction of lung function andmeionectic blood, etc. While senile osteoporosis is closely bound up with therisk factor such as pulmonary fibrosis, diabetes mellitus, smoking, sexuality,age, BMI and so on. Body mass index as a protective factor of osteoporosis canretard bone loss for the elderly in some extend. At the same time, pulmonaryfibrosis has influence on the incidence of osteoporosis in some extent, whichhas a good prospect as the predictors of osteoporosis.