The Preliminary Risk Assessment Research Of Environmental Levels Of Heavy Metals And Trace Elements Exposure On The Women’s Reproductive Health

Objective In order to investigate the incidence of adverse pregnancy outcomes and polycystic ovary syndrome (PCOS), epidemiological data were collected in this study. To discuss the impact of environmental levels of heavy metals and trace elements exposure on adverse pregnancy outcomes, heavy metals and trace elements in newborn cord blood were detected. We detected the levels of heavy metals and trace elements combining with relative hormonal and metabolites, for elucidating the harmful effects of heavy metals and trace elements exposure on PCOS.Methods Using questionnaire survey to collect epidemiological data of1106pregnant women and369age women, and evaluated the impact of environmental factors on adverse pregnancy outcomes and PCOS. We examined heavy metals and trace elements concentrations in179newborn cord blood and201women serum by using inductively coupled plasma mass spectrometry; Using statistical analysis methods such as logistic regression and linear regression to analysis of risk assessment; To further study the possible mechanisms of heavy metals and trace elements on PCOS, we examined metal metabolism-related proteins such as metallothionein, female reproductive hormones such as follicle-stimulating hormone, luteotropic hormone and testosterone, metabolites such as Cholesterol, triglycerides and high/low-density lipoprotein.ResultsFirst, heavy metals and trace elements exposure and adverse pregnancy outcomes1,14kinds of metal elements in newborn cord blood were detected and observed that the concentrations of Sb and Ti in adverse pregnancy outcomes were statistically significant higher than in the controls. The remaining content of heavy metals and trace elements did not show significant differences.2, Further assessment of risk for newborn cord blood Sb and Ti levels and adverse pregnancy outcomes showed that only Ti levels was significantly associated with adverse pregnancy outcomes and showed a dose-dependent manner.Second, heavy metals and trace elements exposure and PCOS 1,15kinds of metal elements in PCOS and controls were detected, and T1, Co, Mn, Ni, Ti, Cu, Zn had a significant difference between PCOS and controls; The levels of these elements in serum were also found significantly associated with PCOS by logistic regression analysis.2, The analysis of correlation between different metal elements and age, MT showed that As was significant positive correlation with age and MT; Ti was only significant positive correlation with age; Cd and Ni were only significant negative correlation with MT; and we also found that metal elements were statistically significant positive correlation with each other. Furthermore, there were positive or negative correlation between T1, Co, Mn, Ni, Ti, Cu, Zn and reproductive hormones and metabolites, respectively, and they were also showed linear relationship in linear regression analysis.3, In a variety of metal elements, Ni and Cu as toxic metals, may contribute to the pathogenesis of PCOS and play an important role in the pathogenesis of PCOS. Zn and Co as essential trace elements, may play a protective role in the pathogenesis of PCOS.