The Clinical Research On The Relationship Of INH, EXC Brain Neurotransmitter In Different TCM Syndrome Stages Of Depressed Patients

ObjectiveThe major depressed patients with different syndromes of their respective characteristics and the relationship between them with Inhibitory and Excitatory brain neurotransmitters level are observed based on the previous study data of the research on neurotransmitter relationship with depression, Thereby, the pathogenesis of depression in different type of TCM syndromes are studied.MethodsThe case control study method was400depressed patients and they were compared and analyzed with the normal subjects. According to TCM, the depression syndromes are divided into5stages,50patients in Liver-Qi stagnation syndrome,62patients in Liver stagnation and Spleen deficiency,95patients in Liver stagnation and phlegm retention,55patients in deficiency of Heart and Spleen syndrome, and138patients in disharmony of Heart and Kidney. The regular pattern of INH and EXC brain neurotransmitter level, and the differences of depressed patients in different genders, ages and TCM syndromes type distribution are observed.The Supper EEG Technology(S-ET) is used to observe the differences of INH and EXC brain neurotransmitters function level. Then, the SPSS17.0statistical software is used for experiment analysis, in a way to observe the differences of INH and EXC neurotransmitter level (low, normal, or hyperthyroidism) in each stages of depression syndromes and to confirm their antagonist relationship.Results(1) The proportion of men and women in depressed patients is1:2.6, which showed that women ratio were significantly higher than men.(2)12%from the total patients are depressed patients between the age of18-40years old (young adults), where41.25%are between the age of41-60years old (middle-aged) and46.75%are between the age of61-78years old (elderly). As it can be seen, the one that easily to get depressed are the elderly.(3) The different precentages of depressed patients in the distribution of TCM syndromes are:12.5%for Liver Qi stagnation,15.5%for Liver stagnation and Spleen deficiency syndrome,23.75%for Liver stagnation and phlegm retention,13.75%for deficiency of Heart and Spleen, and34.5%for the disharmony of Heart and Kidneys. The disharmony of Heart and Kidney group and the Liver stagnation and phlegm retention group have the largest distribution.(4) In depressed patients, INH function at Liver stagnation and phlegm retention group is distinctly higher than at the Liver and Spleen deficiency group and the disharmony of Heart and Kidney group, which the difference was statistically significant (P<0.05P<0.01); INH function at Liver and Spleen deficiency group is distinctly lower than at the Liver stagnation and phlegm retention group, which the difference was statistically significant (P<0.05), as for the rest of the group, the difference was not statistically significant (P>0.05).(5) In depressed patients, EXC function at Liver and Spleen deficiency group is distinctly higher than at the Liver stagnation and phlegm retention group and the deficiency of Heart and Spleen group, which the difference was statistically significant (P<0.01P<0.05); EXC function at Liver stagnation and phlegm retention group is distinctly lower than at the Liver and Spleen deficiency group, which the difference was statistically significant (P<0.01), as for the rest of the group, the difference was not statistically significant (P>0.05).ConclusionsMajor depressed patients have a higher probability occur in women than in men. The largest TCM syndromes distribution of depression patients are at the disharmony of Heart and Kidneys group and the Liver stagnation and phlegm retention group. The result of INH and EXC function in depressed patients compared with the normal subjects are differentiate into3conditions, which are low, normal and hyperthyroidism. INH function is not always in the state of hyperthyroidism and EXC function is not always be in a low state, but instead the performance of INH and EXC are unbalance and not in order. The INH and EXC function in depressed patients at each of TCM syndromes is significantly different. INH has the highest function at the Liver stagnation and phlegm retention syndrome, but at the Liver and Spleen deficiency syndrome has the lowest. On the contrary, the EXC has the highest function at the Liver and Spleen deficiency syndrome but has the lowest function at the Liver stagnation and phlegm retention syndrome. Thus, confirm the antagonistic relationship between INH and EXC function.