| Objective: Diabet mellitus (DM) is a group of metabolic diseases. Thefeature of the DM is chronic blood sugar leelshe, which is caused by thedefects of insulin secretion and (or) function. The population of the patientswith type2diabetes is more than90%. Type2diabetes’ main characteristic isthe lack of insulin relatively. It always happens to adults, especially after theage of35-40. Illness is generally moderate, concealed with a long duration.Type2diabetes merges many complications such as dyslipidemia in theclinical. Dyslipidemia is the abnormal quality and quality of lipid in plasma. Itrelates with a variety of diseases such as obesity, type2diabetes, hypertension,coronary heart disease, and stroke closely. Dyslipidemia can lead to theoccurrence of resistance, hurt beta cells, and involves in the development oftype2diabetes directly. The treatment of modern medicine is symptomatictreatment such as hypoglycemic lipid. It has many adverse reactions in theclinical.The disease belongs to “consumptive thirst” in Traditional ChineseMedicine. And the etiology and pathogenesis are more complex. Manyphysicians in generations mainly conclude the causes of the disease withinadequate endowment, diet dishonor, modern disorders, excessive desires andother aspects. The pathogenesis of “consumptive thirst” is viscera and losses,hot partial, transportation disorder of gas, blood and liquid. The primary aspectis deficiency of yin whereas dryness-heat is the secondary aspect. Professor LiBingmao has studied the field of type2diabetes with dyslipidemia for manyyears in depth. Regarding the mechanism of diabetes, Professor Li putsforward the distinctive opinion. He recognizes that modern diabetes disease islocated in the spleen and stomach. Incidence of the disease is due to insufficiency of the spleen, heat of stomach, abdominal flatulence and internalheat. Its pathogenesis is insufficiency of the spleen and heat of stomach. Itdiffers from the ancient typical pathogenesis, which is deficiency of yin anddryness-heat. It has a difference between deficiency and excess. We believethat the spleen governs transportation and transformation. As the spleen isobstacled in transit, it converges on middle burner and it will turn intoabdominal flatulence. Stomach’s main function is receiving and digesting foodand drink. If stomach fire is exuberant, converges on middle burner, it willturn into internal heat. Professor Li develops Dahuangyushan lipid-loweringmixture based on the theory of syndrome differentiation and treatment. Thetherapeutic principles is nourishing yin to moisten dryness, clearing away heatand resolving blood stasis. It shows good clinical efficacy.In this research, we investigate the effects which conclude the followingaspects the glucose levels(fasting plasma glucose,2-hour postprandial glucose,fructosamine, HbAlc), the lipid levels(total cholesterol, triglycerides,low-density lipoprotein cholesterol, high-density lipoprotein cholesterol) andTCM symptoms by observing the clinical efficacy of treating type2diabeteswith dyslipidemia three months by Dahuangyushan lipid-lowering mixture.Furthermore, we analyze the efficacy of lowing glucose and adjusting lipid.We also observe its unique effect of treating endocrine and metabolic disordersin the ways of multi-component, multi-channel and multi-target.Methods：80patients have been diagnosed as type2diabetic patientswith dyslipidemia(syndromes of insufficiency of the spleen and heat ofstomach) were endocrinology inpatients and outpatients from February2012to October2013in the affiliated to Hebei Medical University, HarrisonInternational Peace Hospital in this study. According to the random principle,they are divided into two groups, one is treatment group and the other is thecontrol group. There are40patients in treatment group and40patients in thecontrol group. There is no significant difference (P>0.05) in age, sex, weight,etc. Both of them are comparable. On the basis of controlling glucoseroutinely, the control group treated with Atorvastatin Capsules,10milligram one time, three times a day. The treatment group treated with Dahuangyushanlipid-lowering mixture (Rhubarb6grams, Polygonatum30grams, Hawthorn20grams, Coptis3grams, Radix notoginseng2grams, Leech3grams). TheseChinese herbal medicines are decocted by water with150milliliters, one timea day. In three months of clinical observation, we make a detailed recordconcluding the patient’s integrations of TCM clinical symptoms, glucose andlipid before and after treatment. We also test the patient’s blood, urine, liverfunction and kidney function. We use statistical methods to process the data.Measurement data is expressed as mean±standard deviation (x±s), in linewith normality and homogeneity of variance by using the t-test, if not, by ranksum test. Count data is studied by rank sum test.Results:1The observation of the overall effect6patients were cured,10patients were markedly effective,16patientswere effective and8patients were ineffective in treatment group, the totaleffective rate of treatment group was80%.2patients were cured,8patientswere markedly effective,10patients were effective and20patients wereineffective in the control group, the total effective rate of the control groupwas50%. We found there was significant difference (P<0.05) in the overallefficiency between the two groups by dealing these results with statistics. Itshowed that Dahuangyushan lipid-lowering mixture was superior toAtorvastatin Capsules in the overall effect.2The observation of TCM clinical symptomsThere was no significant improvement in relieving the symptoms ofshortness of breath and fatigue in the treatment group after treatment. It didn’tshow significant difference between the treatment and control groups (P>0.05).But there was significant improvement in relieving the symptoms of bloating,poor appetite and dry stools in the treatment group after treatment. It alsoshowed significant difference between the treatment and control groups(P<0.05) after treatment. In the aspects of improving the overall context ofTCM syndrome, the total effective rate of the treatment group was90%, the control group was13.3%. The results of observation were statisticallyprocessed, and we found there was significant difference (P<0.05) betweenthe two groups in overall efficiency. It showed that Dahuangyushanlipid-lowering mixture was superior to Atorvastatin Capsules in improving theTCM clinical symptoms of patients, especially relieving the symptoms ofbloating, poor appetite and dry stools.3Comparison of the glucose levelsThe patient’s fasting plasma glucose,2-hour postprandial glucose,fructosamine and HbAlc in the treatment group dropped significantlycompared with the previous glucose levels. After statistical treatment, therewas significant difference in the treatment group after treatment (P<0.05).However, the control group didn’t drop significantly compared with theprevious glucose levels and there was no significant difference in the controlgroup (P>0.05) after statistical treatment. Meanwhile, we made a comparisonbetween the treatment group and the control group, there was significantdifference (P<0.05). It showed that Dahuangyushan lipid-lowering mixturewas superior to Atorvastatin Capsules in lowering the glucose levels ofpatients.4Comparison of the lipid levelsThe patients’ total cholesterol, triglycerides and low-density lipoproteinwere significantly lower whereas high-density lipoprotein improved in varyingdegrees in both of the two groups. The results of observation were statisticallyprocessed, and there was significant difference (P<0.05) between the twogroups after treatment. It showed that Dahuangyushan lipid-lowering mixturewas superior to Atorvastatin Capsules in regulating the lipid levels of patients.Conclusions:1Dahuangyushan lipid-lowering mixture can obviously ease the signsand clinical symptoms of the patients with type2diabetes and dyslipidemia(syndromes of insufficiency of the spleen and heat of stomach), help toimprove the patients’ quality of life.2Dahuangyushan lipid-lowering mixture can drop the glucose (fasting plasma glucose,2-hour postprandial glucose, fructosamine and HbAlc) of thepatients with type2diabetes and dyslipidemia. It can smoothly regulate thelipid (lower total cholesterol, triglycerides and low-density lipoprotein，improve high-density lipoprotein) of patients than Atorvastatin Capsules.Moreover, it can play a significant role in regulating the metabolic disorders ofglucose and lipid, preventing and treating dyslipidemia.3Under the traditional theoretical guidance of TCM, which concludesintegration concept, syndrome differentiation and treatment, Dahuangyushanlipid-lowering mixture puts nourishing yin to moisten dryness, clearing awayheat and resolving blood stasis as the therapeutic principles. According todifferent individuals, we formula along with the disease characteristics,combine the disease with syndrome, and treat the disease in the way ofmultiple targets and individualized therapy. It plays a huge advantage ofstrengthening body’s resistances, eliminating pathogens, and treating bothmanifestation and root causes. |
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