| Objective:To observe the Influence of Compound Danshen decoction on the TGF-β1and VEGI of Myocardial tissues in Rats with acute myocardial ischemiaexplore, and explore the action mechanism.Methods:Sixty Wistar male rats were randomly divided into6groups: distilled water, dongxinluo group, isosorbide dinitrate group, Compound Danshen decoction low, medium, high-dose treatment group. Adaptive feeding1week then hollow irrigation stomach for7days continuously, set up myocardial ischemia model.After the success of the model made from myocardial ischemia in organization, using elisa method to determine the content of TGF-β1and VEGI.Results:1.the Influence of Compound Danshen decoction on the TGF-β1of Myocardial tissues in Rats with acute myocardial ischemiaexplore:the distilled water group was lower significantly than the rest of the group(P<0.05),there is Statistically significant;The tongxinluo group is lower significantly than the isosorbide dinitrate group and Compound Danshen decoction low, medium, high-dose group(P<0.01),there is Statistically significant difference; Compared the isosorbide dinitrate group with Compound Danshen decoction medium, high-dose group, there is no obvious difference(P<0.05),showing no statistically significant; Compared the compound Danshen decoction low-dose group with the isosorbide dinitrate group,there is obvious difference(P<0.05),showing statistically significant; the Compound Danshen decoction low-dose group is lower significantly than the medium, high-dose group(P<0.01),there is Statistically significant; the Compound Danshen decoction medium-dose is higher significantly than the high-dose group(P<0.05),there is Statistically significant.2. the Influence of Compound Danshen decoction on the VEGI of myocardial tissues in Rats with acute myocardial ischemiaexplore:the distilled water group was higher significantly than the rest of the group(P<0.05),there is statistically significant; Compared the tongxinluo group with the isosorbide dinitrate group and Compound Danshen decoction low,medium-dose group,there is statistically significant difference(P<0.05);Compared the isosorbide dinitrate group with Compound Danshen decoction low,medium-dose group, there is no obvious difference(P>0.05), showing no statistically significant;Compared the compound Danshen decoction high-dose group with the isosorbide dinitrate group,there is obvious difference(P<0.01),showing statistically significant;the Compound Danshen decoction high-dose group is higher significantly than the low,medium-dose group(P<0.05),there is Statistically significant; Compound Danshen decoction low-dose group is higher significantly than the medium-dose group(P<0.01),there is Statistically significant.Conclusion:1. the Compound Danshen decoction can increase myocardial tissue’s content of TGF-β1in Rats with acute myocardial ischemiaexplore, the curative effect of the Compound Danshen decoction medium,high-dose group is the same as the isosorbide dinitrate group,but is better than the tongxinluo group;2. the Compound Danshen decoction can decrease the myocardial tissue’s content of VEGI in Rats with acute myocardial ischemiaexplore, the curative effect of the Compound Danshen decoction low, medium-dose group is the same as the isosorbide dinitrate group,but is better than the tongxinluo group. |
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