Reseach On The Preparation Technology And Quality Standard And Preliminary Pharmacodynamic Of The Aerial Roots Of Ficus Microcarpa

Objective: Extracts of the aerial roots of Ficus microcarpa can treatGanglion cyst and Rheumatoid arthritis had proved by Clinical research,this suggest that the aerial roots of Ficus microcarpa may be used to assistGanglion cyst and Rheumatoid arthritis. The aerial roots of Ficus microcarpa were used to study a new assistance for Ganglion cyst and Rheumatoid arthritis in this paper.According to <Medical preparations RegistrationRegulation>of reguest,ongoing the reseach of preparation technology,quality standard and preliminary pharmacodynamic of aerial roots of Ficus microcarpa capsule,which provide reseach data for empolder a new assistance for Ganglion cyst and Rheumatoid arthritis medical preparations.Methods: According to <Medical preparations Registration Regulation>of reguest, ongoing the reseach on the medical preparations–aerial roots of Ficus microcarpa capsule,this include: preparation technology,qualitystandard and preliminary pharmacodynamic research.Reseach on preparationg technology: The total flavonoids and drypaste rate as the index,the single factor and orthogonal test were selected to optimum extracting conditions.Determine optimum parameter of wet granulation by investigate the auxiliary material,bigding material etc.,then establish the final produce technology,and verify the established preparation technology,study the possibility,stability and reliability of the preparation technology.Quality standard reseach of finished product: Draft the qulity controlstandard of finished product by study on the moisture,disintegrating time and content determination.Pharmacodynamic research: Research the anti-inflammatory and analgesic effects of the aerial roots of Ficus microcarpa by xylene induced mouse ear edema model, mouse acetic acid writhing, hot plate method in mice.Results:Determination the finished product dosage form is capsule,contain theaerial roots of Ficus microcarpa and dextrin,use extraction of water decocting method,conventional drying, fill in1#capsule with dextrin.Establishing quality standerd of the aerial roots of Ficus microcarpacapsule,control product quality by the total flavonoids content determination,then draft quality standard.The aerial roots of Ficus microcarpa capsule was stability.shape,identification,moisture,disintegratingtime,content determination,microbial limit testetc. of the aerial roots of Ficus microcarpa capsule were all required standard.the anti-inflammatory and analgesic of the aerial roots of Ficus microcarpacapsule pharmacological effect is good.Through The xylene induced mouse earswelling, mouse acetic acid writhing, hot plate method in mice studies, showedthat the aerial roots of Ficus microcarpa capsule has anti-inflammatory and analgesic effects.Conclusions: According to <Medical preparations Registration Regulation> of request,formulation process is stable,product quality is good and efficacy.