Analysing The Relationship Of Between Location Of Primary Tumor And Liver Metastases For Colorectal Cancer Patients With Liver Metastases

Background and Purpose: Colorectal cancer is one of the mostcommon gastrointestinal malignancies. Metastasis is the major reason ofpoor prognosis in cancer patients. The most ordinary region of metastasisis the liver. Early diagnosis and treatment is the key to improve theprognosis of patients with colorectal cancer. Currently, we depends onimaging as main diagnostic technique to diagnose colorectal cancer withliver metastasis, while the detection rate of imaging is low, especially foroccult metastases. Summary, it’s urgent to find a clear diagnosticapproach to improve patient outcomes. As we all know, colorectal cancerliver metastases is by way of blood metastasis and the process ofcolorectal cancer liver metastases is associated portal venous streamlinedreflux. We explore the simultaneous scatter of metastases of colorectalcarcinoma and the relationship between the primary tumor region and themetastases by the means of imaging systems to explore the relationship. Methods: In this study, a retrospective analysis was applied. Theclinical data and imaging of78patients suffering colorectal cancer withsimultaneous liver metastasis were selected, who were in October2010toSeptember2013in the Cancer Hospital of Guang-Xi Medical University.Primary site of the tumor, numbers of the metastases on CT images, andthe anatomical position(through SPV or SMV or junction) of the inferiormesenteric vein(IMV) terminated were recorded． The result of thestatistical was analyzed by the tatistical software SPSS19.0.Results: Tumor in the right colon of patients of which21cases (84%)in patients with the position of liver metastases mainly in the right lobe,there are4cases in patients with the position of metastatic mainly in theleft lobe of the liver; Primary tumor in the left colon of patients of whichpatients26cases (53.06%) in patients with the location of metastasesmainly in the right lobe of the liver, there are23sicks whose metastaticsare mainly in the left lobe of liver. Metastases between the two groupswere statistically significant differences in the distribution of the liverposition (P<0.05). Patients with primary tumors located in the right colon,the number of metastases in the right lobe was90cases (67.67%) andthere are43metastases in the right lobe of liver. Patients with primarytumors located in the left colon, the number of metastases in the rightlobe was140cases (56.45%) and the number of metastases in the rightlobe was108cases. The difference of composition ratio between the twogroups was statistically significant (P <0.05). Patients with primarytumors located in the left colon whose IMV terminates in SPV: there are5cases (22.73%) with metastatics location mainly in the right lobe ofliver,17sicks (77.27%) with metastatic positions mainly in the left lobe of the liver. Patients with primary tumors located in the left colon whoseIMV terminates in SMV: there are21cases (77.78%) with metastaticslocation mainly in the right lobe of liver,6sicks (22.22%) withmetastatic positions mainly in the left lobe of the liver. Metastasesbetween the two groups were statistically significant differences in thedistribution of the liver position (P<0.05).Patients with primary tumorslocated in the left colon whose IMV terminates in SPV: the number ofmetastases was49cases (40.50%) in the right lobe and72cases (59.50%)in left lobe. Patients with primary tumors located in the left colon whoseIMV terminates in SMV: the number of metastases was91cases (71.65%)in the right lobe and36cases (28.35%) in left lobe. The difference ofcomposition ratio between the two groups was statistically significant (P<0.05).Conclusions: There is a certain relationship between the position ofprimary tumor of CRC and the distribution of liver metastasis. Theprimary location of colorectal may direct us the judgment for the positionof liver metastases; When liver is surgical explored, for CRC patients,wecan focus on the exploration of the left lobe of liver or the right lobe ofthe liver through the position of primary tumor of CRC and theanatomical position of the inferior mesenteric vein(IMV) terminated tofuther reduce the possibility of missed diagnosis of liver metastases.