The Clinical Research Of Index Of Consciousness To Monitor The Depth Of Anesthesia

PART I USE OF INDEX OF CONSCIOUSNESS TO MONITOR DEPTH OF ANESTHESIA INSEVOFLURANE-ANESTHETIZED CHILDREN: COMPARED WITH BIS VALUESObjective To examine the correlation between Index of Consciousness (IoC) and the depth of anesthesia in children with sevoflurane inhalation anesthesia and compared with BIS values.Methods Forty-two children with abdominal surgery under general anesthesia, ASA class I or II, any gender, ages8to12years old. Inhaled sevoflurane induced by endotracheal intubation after adjust the concentration of sevoflurane inhaled, make out at the end of the concentration of sevoflurane (CETSev) were maintained at1.6%,2.1%,2.6%,3.1%,3.6%,4.1%and4.6%for at least five minutes, synchronous record IoC value, the BIS value and HR and BP.Results WhenCETSev<3.1%, the correlation coefficients between CETSev and IoC and BIS values were-0.927(r1) and-0.869(r2) whereas when3.1%≤CETSev≤4.6%, the correlation coefficients were-0.808(r3) and-0.430(r4), respectively. Comparison of absolute value of correlation coefficients:no significant difference between r1, r2and r3(P>0.05); r1, r2and r3were significantly higher compared with r4(P<0.01). Conclusions When CETSev≤3.1%, IoC values could accurately reflect the depth of anesthesia; when3.1%≤CETSev≤4.6%, the accuracy of IoC values for monitoring the depth of anesthesia is superior to that of BIS values. PART II THE FEASIBILITY OF INDEX OF CONSCIOUSNESS TO MONITOR DEPTH OF ANESTHESIA IN ARTIFICIAL ABORTION SURGERYObjective To examine the feasibility of using Index of Consciousness (IoC) for monitoring the sedation depth with propofol in artificial abortion surgery.Methods one hundred ASA I or II patients aged20-30yr undergoing artificial abortion surgery were randomly divided into2groups:IoC group and standard clinical group (n=50, each) both received a propofol/fentanyl anesthesia, according to the target plasma concentrations of propofol administered by TCI during induction of anesthesia.The initial plasma propofol concentration was4.0ug/ml and infuse fentanyl1.0ug/kg slowly.Clinical group evaluate the sedation depth using the modified OAA/S score and infuse propofol continuously until OAA/S score was one(one=does not respond to prodding),change the target plasma concentrations of propofol according to hemodynamics. IoC group infuse propofol continuously until IoC drop to60～40and maintain IoC45±3, change the target plasma concentrations of propofol according to IoC. Record BP、HR、SpO2、the amount of propofol、the recovery time and orientation time and observe the side effects.Results Compared with clinical group,the amount of propofol was smaller, the recovery time and orientation time were shorter and the incidence of body during operation was lower in IoC group (P<0.05).Conclusion Index of Consciousness has guiding significance to control the sedation depth with propofol in artificial abortion surgery.