"The Curative Effect Of Perindopril On Hypertension Of Elderly Patients"

Objective:To observe the antihypertensive effect and the effect on renal function of Perindopril in patients with essential hypertension. Methods:Consecutive54elderly patients with essential hypertension were randomly divided into two groups, the patients in low-dose group were treated with perindopril4mg once a day; patients in high-dose group were treated with perindopril8mg once a day. Blood pressure, renal function and24h urinary albumin quantification was assessed at baseline and1,3,6months during follow-up. Results:After treatment of6months, perindopril resulted in significant reduction in both systolic and diastolic blood pressure (p<0.05). Serum creatinine, blood urea nitrogen and24h urine albumin also decreased significantly after treatment of perindopril (p<0.05). And the changes were more pronounced in high-dose group than lower dose group. Conclusion: Perindopril has exact antihypertensive effect in patients with essential hypertension, and it can reduce proteinuria and improve renal function, and thus slow down the process of renal insufficiency.