A Preliminary Study On The Correlation Between Serum 25 Hydroxyvitamin D And TCM Syndromes And Cardio-renal Function Of Hypertension

Objective:To study the difference of 25-Hydroxyvitamin D(25(OH)D)level among different traditional Chinese medicine(TCM)syndromes in patients with essential hypertension,and the correlation between 25(OH)D level and cardio-renal function in patients with essential hypertension,and to explore the effect of 25(OH)D level on cardio-renal function in patients with EH.Methods:According to the inclusion and exclusion criteria,150 EH patients admitted to Nanjing Hospital of Traditional Chinese Medicine were selected.The general situation of the patients was investigated,and the TCM syndrome differentiation and classification was carried out according to the symptoms and tongue coating pulse.Fasting serum and clean middle urine were collected from the patients after fasting and drinking for more than 8 hours.The retinol binding protein,cystatin C,25(OH)D,urinary microalbumin,urinary αl microglobulin,urinary β2 microglobulin,and urinary NAG enzyme were detected respectively.Echocardiography was collected by the heart function room of Nanjing Hospital of Traditional Chinese Medicine.Results:1.The levels of 25(OH)D in EH patients were different in different smoking and drinking history,different age levels and different BMI levels,and the differences were statistically significant(P<0.05).2.TCM syndromes were different in EH patients with different drinking history,different age levels and different BMI levels,and the difference was statistically significant(P<0.05).3.The difference of 25(OH)D level in different TCM syndromes of EH patients was statistically significant(P<0.001),and the 25(OH)D level from high to low was:hyperactivity of liver-yang>stasis blocking channels>phlegm turbidity yongsheng>deficiency of liver-yin and kidney-yin.4.25(OH)D level was negatively correlated with LAD IVSD,LVPWD,LVDD,RWT,LVMI in EH patients(P<0.05,rs=-0.173,-0.259,-0.280,-0.162,-0.228,-0.233).5.25(OH)D level was negatively correlated with RBP and urinary NAG in EH patients(P<0.05,rs=-0.300,-0.202).6.25(OH)D levels in EH patients with different Umalb,urinaryβ2-MG,urinary αl-MG levels of distribution difference was statistically significant(P<0.05),and abnormal group was lower than the normal group.7.BMI was an independent risk factor for 25(OH)D deficiency in EH patients,and had certain predictive significance for 25(OH)D deficiency in EH patients(P=0.001<0.01).The predictive threshold value of BMI was 25.18kg/m2,specificity=0.656,sensitivity=0.651.Conclusion:1.There was a certain correlation between TCM syndrome type and serum 25(OH)D level and risk factors(drinking history,obesity,advanced age)in patients with hypertension.2.The level of 25(OH)D in patients with hypertension was correlated with the history of alcohol consumption,smoking,age and BMI to some extent,and BMI was an independent risk factor for hypertension complicated with 25(OH)D deficiency.The BMI level of patients with hypertension complicated with 25(OH)D deficiency had certain predictive significance.3.The level of 25(OH)D in patients with hypertension has a certain correlation with cardiac function,and the hypertension patients with 25(OH)D deficiency may be more prone to cardiac damage.4.The level of 25(OH)D in hypertensive patients is correlated with renal function to a certain extent.Hypertensive patients with 25(OH)D deficiency may be more prone to renal damage.